3-oxo-2-(2-(2-(trifluoromethoxy)phenyl)hydrazono)butanoic acid ethyl ester

Base Information

Chemical Name:3-oxo-2-(2-(2-(trifluoromethoxy)phenyl)hydrazono)butanoic acid ethyl ester
CAS No.:1620683-57-9
Molecular Formula:C₁₃H₁₃F₃N₂O₄
Molecular Weight:318.252
Hs Code.:

Synonyms:3-oxo-2-(2-(2-(trifluoromethoxy)phenyl)hydrazono)butanoic acid ethyl ester

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Chemical Property of 3-oxo-2-(2-(2-(trifluoromethoxy)phenyl)hydrazono)butanoic acid ethyl ester

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Technology Process of 3-oxo-2-(2-(2-(trifluoromethoxy)phenyl)hydrazono)butanoic acid ethyl ester

There total 1 articles about 3-oxo-2-(2-(2-(trifluoromethoxy)phenyl)hydrazono)butanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.3%

: 1535-75-7
2-trifluoromethoxy aniline

: 141-97-9
ethyl acetoacetate

: 1620683-57-9
3-oxo-2-(2-(2-(trifluoromethoxy)phenyl)hydrazono)butanoic acid ethyl ester

Guidance literature:: 2-trifluoromethoxy aniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

ethyl acetoacetate; With sodium acetate; In ethanol; water; at 0 ℃;
DOI:10.1016/j.ejmech.2014.06.068

Reference yield: 51.4%

: 1620683-57-9
3-oxo-2-(2-(2-(trifluoromethoxy)phenyl)hydrazono)butanoic acid ethyl ester

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 1620683-61-5
ethyl 4-methyl-6-oxo-1-(2-(trifluoromethoxy)phenyl)-1,6-dihydropyridazine-3-carboxylate

Guidance literature:: In toluene; for 12h; Reflux;
DOI:10.1016/j.ejmech.2014.06.068

Reference yield:

: 1620683-57-9
3-oxo-2-(2-(2-(trifluoromethoxy)phenyl)hydrazono)butanoic acid ethyl ester

: 1620683-69-3
4-methyl-6-oxo-1-(2-(trifluoromethoxy)phenyl)-1,6-dihydropyridazine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 12 h / Reflux

2: sodium hydroxide / tetrahydrofuran / 4 h / 50 °C

With sodium hydroxide; In tetrahydrofuran; toluene;
DOI:10.1016/j.ejmech.2014.06.068