4-(tert-butyldimethylsilyl)-1,3,4-trihydroxy-1-phenylbutan-2-yl diisopropylcarbamate

Base Information

Chemical Name:4-(tert-butyldimethylsilyl)-1,3,4-trihydroxy-1-phenylbutan-2-yl diisopropylcarbamate
CAS No.:1443780-06-0
Molecular Formula:C₂₃H₄₁NO₅Si
Molecular Weight:439.668
Hs Code.:

Synonyms:4-(tert-butyldimethylsilyl)-1,3,4-trihydroxy-1-phenylbutan-2-yl diisopropylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(tert-butyldimethylsilyl)-1,3,4-trihydroxy-1-phenylbutan-2-yl diisopropylcarbamate

Chemical Property:

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Technology Process of 4-(tert-butyldimethylsilyl)-1,3,4-trihydroxy-1-phenylbutan-2-yl diisopropylcarbamate

There total 4 articles about 4-(tert-butyldimethylsilyl)-1,3,4-trihydroxy-1-phenylbutan-2-yl diisopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: (E)-4-(tert-butyldimethylsilyl)-1-hydroxy-1-phenylbut-3-en-2-yl diisopropylcarbamate

: 1443780-06-0
4-(tert-butyldimethylsilyl)-1,3,4-trihydroxy-1-phenylbutan-2-yl diisopropylcarbamate

Guidance literature:: With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In acetone; acetonitrile; at 20 ℃; for 3h;
DOI:10.1016/j.tet.2013.05.043

Reference yield:

: 1443780-03-7
(E)-3-(tert-butyldimethylsilyl)allyl diisopropylcarbamate

: 1443780-06-0
4-(tert-butyldimethylsilyl)-1,3,4-trihydroxy-1-phenylbutan-2-yl diisopropylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / hexane; tetrahydrofuran / 0.08 h / -80 °C

1.2: 0 h / -80 °C

2.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / acetonitrile; acetone / 3 h / 20 °C

With osmium(VIII) oxide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; 4-methylmorpholine N-oxide; In tetrahydrofuran; hexane; acetone; acetonitrile;
DOI:10.1016/j.tet.2013.05.043

Reference yield:

: 19009-39-3
N,N-diisopropylcarbamoyl chloride

: 1443780-06-0
4-(tert-butyldimethylsilyl)-1,3,4-trihydroxy-1-phenylbutan-2-yl diisopropylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / -80 °C

1.2: 0.42 h / -80 - 0 °C

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / hexane; tetrahydrofuran / 0.08 h / -80 °C

2.2: 0 h / -80 °C

3.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / acetonitrile; acetone / 3 h / 20 °C

With osmium(VIII) oxide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; potassium hexamethylsilazane; 4-methylmorpholine N-oxide; In tetrahydrofuran; hexane; acetone; acetonitrile;
DOI:10.1016/j.tet.2013.05.043