C₃₅H₅₂O₃S₃

Base Information

• Chemical Name: C₃₅H₅₂O₃S₃
• CAS No.: 137435-90-6
• Molecular Formula: C₃₅H₅₂O₃S₃
• Molecular Weight: 616.994
• Mol file: 137435-90-6.mol

Synonyms:C₃₅H₅₂O₃S₃

Chemical Property of C₃₅H₅₂O₃S₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₅H₅₂O₃S₃

There total 16 articles about C₃₅H₅₂O₃S₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6β-methoxy-3α,5-cyclo-5α-chol-23-en-22-ol (57984-04-0,71424-84-5,71424-85-6) → C35H52O3S3 (137435-90-6)

Guidance literature:

Multi-step reaction with 15 steps

1: 76 percent / propionic acid / xylene / 3 h / Heating

2: 100 percent / H₂ / PtO₂ / hexane / 30 h / 760 Torr

3: 6.7 g / LAH / diethyl ether / 0.5 h / Ambient temperature

4: 98 percent / imidazole / dimethylformamide / 1 h

5: 89 percent / 0.67 h / Heating

6: 50 percent / N-bromosuccinimide (NBS), aq. HClO₄ / 1.5 h / 0 - 20 °C

7: 75 percent / Pb(OAc)4, CaCO₃, I₂ / cyclohexane / 3 h / Heating; Irradiation

8: 1.10 g / KOH / methanol / 0.5 h / Heating

9: 8 N Jones' reagent / acetone / 1 h / 0 °C

10: 62 percent / Zn, i-PrOH / dimethylformamide / 8 h / Heating

11: 89 percent / 8 N Jones' reagent / acetone / 2 h / 0 °C

12: 86 percent / triethylamine (TEA) / 0.5 h / Heating

13: 83 percent / trimethylsilyl trifluoromethanesulfonate (TMSOTf) / CH₂Cl₂ / 5 h / -78 - -23 °C

14: 76 percent / TBAF / tetrahydrofuran / 18 h

15: pyridine, DMAP / 22 h

With pyridine; 1H-imidazole; lead(IV) acetate; dmap; potassium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; perchloric acid; jones' reagent; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; hydrogen; iodine; propionic acid; triethylamine; isopropyl alcohol; calcium carbonate; zinc; platinum(IV) oxide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; cyclohexane; N,N-dimethyl-formamide; acetone; xylene;

Reference yield:

ethyl (25ξ,22E)-6β-methoxy-3α,5-cyclo-5α-cholest-22-en-26-oate (137436-15-8) → C35H52O3S3 (137435-90-6)

Guidance literature:

Multi-step reaction with 14 steps

1: 100 percent / H₂ / PtO₂ / hexane / 30 h / 760 Torr

2: 6.7 g / LAH / diethyl ether / 0.5 h / Ambient temperature

3: 98 percent / imidazole / dimethylformamide / 1 h

4: 89 percent / 0.67 h / Heating

5: 50 percent / N-bromosuccinimide (NBS), aq. HClO₄ / 1.5 h / 0 - 20 °C

6: 75 percent / Pb(OAc)4, CaCO₃, I₂ / cyclohexane / 3 h / Heating; Irradiation

7: 1.10 g / KOH / methanol / 0.5 h / Heating

8: 8 N Jones' reagent / acetone / 1 h / 0 °C

9: 62 percent / Zn, i-PrOH / dimethylformamide / 8 h / Heating

10: 89 percent / 8 N Jones' reagent / acetone / 2 h / 0 °C

11: 86 percent / triethylamine (TEA) / 0.5 h / Heating

12: 83 percent / trimethylsilyl trifluoromethanesulfonate (TMSOTf) / CH₂Cl₂ / 5 h / -78 - -23 °C

13: 76 percent / TBAF / tetrahydrofuran / 18 h

14: pyridine, DMAP / 22 h

With pyridine; 1H-imidazole; lead(IV) acetate; dmap; potassium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; perchloric acid; jones' reagent; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; hydrogen; iodine; triethylamine; isopropyl alcohol; calcium carbonate; zinc; platinum(IV) oxide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; cyclohexane; N,N-dimethyl-formamide; acetone;

Reference yield:

(R)-6-((1aR,3aR,3bS,5aR,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-2-methyl-heptan-1-ol (137435-76-8,137435-77-9) → C35H52O3S3 (137435-90-6)

Guidance literature:

Multi-step reaction with 12 steps

1: 98 percent / imidazole / dimethylformamide / 1 h

2: 89 percent / 0.67 h / Heating

3: 50 percent / N-bromosuccinimide (NBS), aq. HClO₄ / 1.5 h / 0 - 20 °C

4: 75 percent / Pb(OAc)4, CaCO₃, I₂ / cyclohexane / 3 h / Heating; Irradiation

5: 1.10 g / KOH / methanol / 0.5 h / Heating

6: 8 N Jones' reagent / acetone / 1 h / 0 °C

7: 62 percent / Zn, i-PrOH / dimethylformamide / 8 h / Heating

8: 89 percent / 8 N Jones' reagent / acetone / 2 h / 0 °C

9: 86 percent / triethylamine (TEA) / 0.5 h / Heating

10: 83 percent / trimethylsilyl trifluoromethanesulfonate (TMSOTf) / CH₂Cl₂ / 5 h / -78 - -23 °C

11: 76 percent / TBAF / tetrahydrofuran / 18 h

12: pyridine, DMAP / 22 h

With pyridine; 1H-imidazole; lead(IV) acetate; dmap; potassium hydroxide; N-Bromosuccinimide; perchloric acid; jones' reagent; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; iodine; triethylamine; isopropyl alcohol; calcium carbonate; zinc; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; N,N-dimethyl-formamide; acetone;

upstream raw materials:

(25ξ)-26-hydroxy-19-norcholest-5(10)-en-3-one 3-(ethylene thioketal)

p-toluenesulfonyl chloride

(R)-6-((1aR,3aR,3bS,5aR,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-2-methyl-heptan-1-ol

6β-methoxy-3α,5-cyclo-5α-chol-23-en-22-ol

Downstream raw materials:

19-norcholest-4-en-3-one

Refernces