2-iodo-N-{2-[(1-phenyl-ethylamino)-methyl]-benzyl}-N-propa-1,2-dienyl-benzamide

Base Information

Chemical Name:2-iodo-N-{2-[(1-phenyl-ethylamino)-methyl]-benzyl}-N-propa-1,2-dienyl-benzamide
CAS No.:357979-88-5
Molecular Formula:C₂₆H₂₅IN₂O
Molecular Weight:508.402
Hs Code.:

2-iodo-<i>N</i>-{2-[(1-phenyl-ethylamino)-methyl]-benzyl}-<i>N</i>-propa-1,2-dienyl-benzamide

Synonyms:2-iodo-N-{2-[(1-phenyl-ethylamino)-methyl]-benzyl}-N-propa-1,2-dienyl-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-iodo-N-{2-[(1-phenyl-ethylamino)-methyl]-benzyl}-N-propa-1,2-dienyl-benzamide

Chemical Property:

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Technology Process of 2-iodo-N-{2-[(1-phenyl-ethylamino)-methyl]-benzyl}-N-propa-1,2-dienyl-benzamide

There total 10 articles about 2-iodo-N-{2-[(1-phenyl-ethylamino)-methyl]-benzyl}-N-propa-1,2-dienyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-iodo-N-{2-[(1-phenyl-ethylamino)-methyl]-benzyl}-N-prop-2-ynyl-benzamide

: 357979-88-5
2-iodo-N-{2-[(1-phenyl-ethylamino)-methyl]-benzyl}-N-propa-1,2-dienyl-benzamide

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.0166667h;
DOI:10.1039/b102046n

Reference yield:

: 35849-09-3
o-bromobenzaldehyde dimethyl acetal

: 357979-88-5
2-iodo-N-{2-[(1-phenyl-ethylamino)-methyl]-benzyl}-N-propa-1,2-dienyl-benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: 98 percent / tetrahydrofuran / -78 - 20 °C

2.1: 100 percent / MgSO₄ / CH₂Cl₂

3.1: 95 percent / NaBH₄ / methanol / 0 °C

4.1: 69 percent / TEA / CH₂Cl₂ / 0 - 20 °C

5.1: 97 percent / Montmorillonite K₁₀ / CH₂Cl₂ / 0.17 h / 20 °C

6.1: MgSO₄ / CH₂Cl₂

7.1: NaBH₄ / methanol / 0.17 h / 0 °C

8.1: t-BuOK / tetrahydrofuran / 0.02 h / 0 °C

With sodium tetrahydroborate; n-butyllithium; Montmorillonite K₁₀; TEA; potassium tert-butylate; magnesium sulfate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/b102046n

Reference yield:

: 132233-84-2
2-(dimethoxymethyl)benzaldehyde

: 357979-88-5
2-iodo-N-{2-[(1-phenyl-ethylamino)-methyl]-benzyl}-N-propa-1,2-dienyl-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / MgSO₄ / CH₂Cl₂

2: 95 percent / NaBH₄ / methanol / 0 °C

3: 69 percent / TEA / CH₂Cl₂ / 0 - 20 °C

4: 97 percent / Montmorillonite K₁₀ / CH₂Cl₂ / 0.17 h / 20 °C

5: MgSO₄ / CH₂Cl₂

6: NaBH₄ / methanol / 0.17 h / 0 °C

7: t-BuOK / tetrahydrofuran / 0.02 h / 0 °C

With sodium tetrahydroborate; Montmorillonite K₁₀; TEA; potassium tert-butylate; magnesium sulfate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/b102046n