[3-((4R,5S,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-5-((2R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yl)-furan-2-yl]-bromomethyl-dimethyl-silane

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Chemical Name:[3-((4R,5S,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-5-((2R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yl)-furan-2-yl]-bromomethyl-dimethyl-silane
CAS No.:628725-17-7
Molecular Formula:C₄₃H₅₅BrO₉Si
Molecular Weight:823.894
Hs Code.:

[3-((4R,5S,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-5-((2R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yl)-furan-2-yl]-bromomethyl-dimethyl-silane

Synonyms:[3-((4R,5S,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-5-((2R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yl)-furan-2-yl]-bromomethyl-dimethyl-silane

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Chemical Property of [3-((4R,5S,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-5-((2R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yl)-furan-2-yl]-bromomethyl-dimethyl-silane

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Technology Process of [3-((4R,5S,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-5-((2R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yl)-furan-2-yl]-bromomethyl-dimethyl-silane

There total 1 articles about [3-((4R,5S,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-5-((2R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yl)-furan-2-yl]-bromomethyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 16532-02-8
bromomethyldimethylsilyl chloride

: C₄₀H₄₈O₉

: 628725-17-7
[3-((4R,5S,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-5-((2R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yl)-furan-2-yl]-bromomethyl-dimethyl-silane

Guidance literature:: C₄₀H₄₈O₉; With lithium diisopropyl amide; In tetrahydrofuran;

bromomethyldimethylsilyl chloride; In tetrahydrofuran;
DOI:10.1021/ja0375582

Reference yield: 88.0%

: 2423-72-5
2,6-dichloro-4-methoxyphenol

: 628725-17-7
[3-((4R,5S,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-5-((2R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yl)-furan-2-yl]-bromomethyl-dimethyl-silane

: 628725-18-8
[3-((4R,5S,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-5-((2R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yl)-furan-2-yl]-(2,6-dichloro-4-methoxy-phenoxymethyl)-dimethyl-silane

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetone;
DOI:10.1021/ja0375582

Reference yield:

: 628725-17-7
[3-((4R,5S,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-5-((2R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yl)-furan-2-yl]-bromomethyl-dimethyl-silane

: 2-((2R,4R,5S,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-7-chloro-4-((2R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yl)-5,8-dimethoxy-1,4-dihydro-naphthalen-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / tetrabutylammonium iodide; K₂CO₃ / acetone

2: 61 percent / t-BuLi / tetrahydrofuran / -90 - -10 °C

3: tetrabutylammonium fluoride / dimethylformamide / 20 °C

4: 72 percent / trifluoroacetic acid / CH₂Cl₂ / 0 - 20 °C

With tetrabutyl ammonium fluoride; tert.-butyl lithium; tetra-(n-butyl)ammonium iodide; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja0375582