(S)-[((S)-2-Benzyloxycarbonylamino-propionyl)-methyl-amino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid

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Chemical Name:(S)-[((S)-2-Benzyloxycarbonylamino-propionyl)-methyl-amino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid
CAS No.:93806-88-3
Molecular Formula:C₂₂H₂₆N₄O₁₀
Molecular Weight:506.469
Hs Code.:

(S)-[((S)-2-Benzyloxycarbonylamino-propionyl)-methyl-amino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid

Synonyms:(S)-[((S)-2-Benzyloxycarbonylamino-propionyl)-methyl-amino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid

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Chemical Property of (S)-[((S)-2-Benzyloxycarbonylamino-propionyl)-methyl-amino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid

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Technology Process of (S)-[((S)-2-Benzyloxycarbonylamino-propionyl)-methyl-amino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid

There total 3 articles about (S)-[((S)-2-Benzyloxycarbonylamino-propionyl)-methyl-amino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24695-48-5
1-(5'-amino-5'-deoxy-α-D-allofuranuronosyl)uracil

: 93806-88-3
(S)-[((S)-2-Benzyloxycarbonylamino-propionyl)-methyl-amino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / aq. NaOH, NaBH₄

2: 82 percent / NaBH₃CN / methanol / 0.33 h

3: 60 percent / AcOH, H₂ / 5percent Pd/BaSO₄ / H₂O

4: Et₃N / dimethylformamide; H₂O / 48 h

With sodium hydroxide; sodium tetrahydroborate; hydrogen; sodium cyanoborohydride; acetic acid; triethylamine; Pd-BaSO₄; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00381a012

Reference yield:

: 93842-00-3
1-<5'-(benzylmethylamino)-5'-deoxy-β-D-allofuranosyluronic acid>uracil

: 93806-88-3
(S)-[((S)-2-Benzyloxycarbonylamino-propionyl)-methyl-amino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / AcOH, H₂ / 5percent Pd/BaSO₄ / H₂O

2: Et₃N / dimethylformamide; H₂O / 48 h

With hydrogen; acetic acid; triethylamine; Pd-BaSO₄; In water; N,N-dimethyl-formamide;
DOI:10.1021/jm00381a012

Reference yield:

: 93806-85-0
1-<5'-(benzylamino)-5'-deoxy-β-D-allofuranosyluronic acid>uracil

: 93806-88-3
(S)-[((S)-2-Benzyloxycarbonylamino-propionyl)-methyl-amino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / NaBH₃CN / methanol / 0.33 h

2: 60 percent / AcOH, H₂ / 5percent Pd/BaSO₄ / H₂O

3: Et₃N / dimethylformamide; H₂O / 48 h

With hydrogen; sodium cyanoborohydride; acetic acid; triethylamine; Pd-BaSO₄; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00381a012