2-(3-(benzyloxy)-5-fluorophenyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide

Base Information

• Chemical Name: 2-(3-(benzyloxy)-5-fluorophenyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide
• CAS No.: 1245607-52-6
• Molecular Formula: C₂₀H₁₆FNO₃S
• Molecular Weight: 369.416

Synonyms:2-(3-(benzyloxy)-5-fluorophenyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide

Chemical Property of 2-(3-(benzyloxy)-5-fluorophenyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide

Chemical Property:

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Technology Process of 2-(3-(benzyloxy)-5-fluorophenyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide

There total 6 articles about 2-(3-(benzyloxy)-5-fluorophenyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-(3-(benzyloxy)-5-fluorophenyl)-2-(hydroxymethyl)benzenesulfonamide → 2-(3-(benzyloxy)-5-fluorophenyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide (1245607-52-6)

Guidance literature:

With phosphorus tribromide; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b00685

Reference yield:

1-(benzyloxy)-3-fluoro-5-nitrobenzene → 2-(3-(benzyloxy)-5-fluorophenyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide (1245607-52-6)

Guidance literature:

Multi-step reaction with 4 steps

1: tin(ll) chloride / ethanol; water; acetonitrile / 1 h / Inert atmosphere; Reflux

2: pyridine / 16 h / 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

4: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; phosphorus tribromide; tin(ll) chloride; In tetrahydrofuran; ethanol; water; acetonitrile;

DOI:10.1021/acs.jmedchem.6b00685

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 2-(3-(benzyloxy)-5-fluorophenyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide (1245607-52-6)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

2: tin(ll) chloride / ethanol; water; acetonitrile / 1 h / Inert atmosphere; Reflux

3: pyridine / 16 h / 20 °C / Inert atmosphere

4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

5: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; phosphorus tribromide; potassium carbonate; tin(ll) chloride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/acs.jmedchem.6b00685

upstream raw materials:

benzyl alcohol

3-(benzyloxy)-5-fluoroaniline

Downstream raw materials:

2-(3-fluoro-5-hydroxyphenyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide

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