(R)-6-((1-cyclopropylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile

Base Information

Chemical Name:(R)-6-((1-cyclopropylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile
CAS No.:1621911-87-2
Molecular Formula:C₁₉H₁₇F₃N₆
Molecular Weight:386.379
Hs Code.:

Synonyms:(R)-6-((1-cyclopropylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile

Suppliers and Price of (R)-6-((1-cyclopropylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-6-((1-cyclopropylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-6-((1-cyclopropylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile

There total 4 articles about (R)-6-((1-cyclopropylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1621911-88-3
(R)-2-chloro-N-(1-cyclopropylethyl)-7-(4-(trifluoromethyl)benzyl)-7H-purin-6-amine

: 1621911-87-2
(R)-6-((1-cyclopropylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile

Guidance literature:: With bis(η3-allyl-μ-chloropalladium(II)); XPhos; In N,N-dimethyl acetamide; at 120 ℃; for 2h; Inert atmosphere;

Reference yield:

: 5451-40-1
2,6-dichloro-7H-purine

: 1621911-87-2
(R)-6-((1-cyclopropylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium t-butanolate / tetrahydrofuran / Inert atmosphere

1.2: Reflux; Inert atmosphere

2.1: triethylamine / isopropyl alcohol / 2 h / 80 °C

3.1: bis(η3-allyl-μ-chloropalladium(II)); XPhos / N,N-dimethyl acetamide / 2 h / 120 °C / Inert atmosphere

With bis(η3-allyl-μ-chloropalladium(II)); triethylamine; sodium t-butanolate; XPhos; In tetrahydrofuran; N,N-dimethyl acetamide; isopropyl alcohol;

Reference yield:

: 402-49-3
4-bromomethyltrifluoromethylbenzene

: 1621911-87-2
(R)-6-((1-cyclopropylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium t-butanolate / tetrahydrofuran / Inert atmosphere

1.2: Reflux; Inert atmosphere

2.1: triethylamine / isopropyl alcohol / 2 h / 80 °C

3.1: bis(η3-allyl-μ-chloropalladium(II)); XPhos / N,N-dimethyl acetamide / 2 h / 120 °C / Inert atmosphere

With bis(η3-allyl-μ-chloropalladium(II)); triethylamine; sodium t-butanolate; XPhos; In tetrahydrofuran; N,N-dimethyl acetamide; isopropyl alcohol;