5-amino-1-[(3R,6S)-1-cyano-6-methylpiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:5-amino-1-[(3R,6S)-1-cyano-6-methylpiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazole-4-carboxamide
CAS No.:1609466-98-9
Molecular Formula:C₂₃H₂₂F₂N₆O₂
Molecular Weight:452.463
Hs Code.:

Synonyms:5-amino-1-[(3R,6S)-1-cyano-6-methylpiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazole-4-carboxamide

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Chemical Property of 5-amino-1-[(3R,6S)-1-cyano-6-methylpiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazole-4-carboxamide

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Technology Process of 5-amino-1-[(3R,6S)-1-cyano-6-methylpiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazole-4-carboxamide

There total 16 articles about 5-amino-1-[(3R,6S)-1-cyano-6-methylpiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-amino-1-[(3R*,6S*)-1-cyano-6-methylpiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazole-4-carboxamide

: 1609466-98-9
5-amino-1-[(3R,6S)-1-cyano-6-methylpiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazole-4-carboxamide

: 1609466-99-0
5-amino-1-[(3S,6R)-1-cyano-6-methylpiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazole-4-carboxamide

Guidance literature:: With regispak; In ethanol; Resolution of racemate;

Reference yield:

: 1044060-43-6
methyl 4-(2,4-difluorophenoxy)benzoate

: 1609466-98-9
5-amino-1-[(3R,6S)-1-cyano-6-methylpiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazole-4-carboxamide

: 1609466-99-0
5-amino-1-[(3S,6R)-1-cyano-6-methylpiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: water; sodium hydroxide / methanol / 3 h / 0 - 50 °C

2.1: thionyl chloride / Reflux

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: 3 h / 20 °C

3.3: 18 h / Reflux

4.1: triethylamine / ethanol / 16 h / 20 °C

5.1: sulfuric acid / 16 h / 0 - 30 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

7.1: regispak / ethanol / Resolution of racemate

With thionyl chloride; sulfuric acid; water; sodium hydride; caesium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: (2S*,5R*)benzyl 5-(5-amino-4-cyano-3-(4-(2,4-difluorophenoxy)phenyl)-1H-pyrazol-1-yl)-2-methylpiperidine-1-carboxylate

: 1609466-98-9
5-amino-1-[(3R,6S)-1-cyano-6-methylpiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazole-4-carboxamide

: 1609466-99-0
5-amino-1-[(3S,6R)-1-cyano-6-methylpiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 16 h / 0 - 30 °C

2: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

3: regispak / ethanol / Resolution of racemate

With sulfuric acid; caesium carbonate; In ethanol; N,N-dimethyl-formamide;