4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)benzoic (isobutylcarbonic)anhydride

Base Information

Chemical Name:4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)benzoic (isobutylcarbonic)anhydride
CAS No.:1189852-18-3
Molecular Formula:C₁₅H₁₇F₃O₅
Molecular Weight:334.292
Hs Code.:

Synonyms:4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)benzoic (isobutylcarbonic)anhydride

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Chemical Property of 4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)benzoic (isobutylcarbonic)anhydride

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Technology Process of 4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)benzoic (isobutylcarbonic)anhydride

There total 3 articles about 4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)benzoic (isobutylcarbonic)anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 917771-42-7
4-(2,2,2-trifluoro-1-hydroxy-1-methyl-ethyl)benzoic acid

: 543-27-1
isobutyl chloroformate

: 1189852-18-3
4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)benzoic (isobutylcarbonic)anhydride

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 917771-41-6
4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)benzoic acid methyl ester

: 1189852-18-3
4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)benzoic (isobutylcarbonic)anhydride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol / 2 h / 50 °C

1.2: 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol;

Reference yield:

: 3609-53-8
methyl 4-acetylbenzoate

: 1189852-18-3
4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)benzoic (isobutylcarbonic)anhydride

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C

2.1: sodium hydroxide / methanol / 2 h / 50 °C

2.2: 20 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

With tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol;