Technology Process of 3-cyano-N-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5dihydroisoxazol-3-yl]-2-methylthiophen-3-ylmethyl}propionamide
There total 7 articles about 3-cyano-N-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5dihydroisoxazol-3-yl]-2-methylthiophen-3-ylmethyl}propionamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium acetate; bromine / water / 12 h / 20 °C
2.1: lithium hydride / tetrahydrofuran / 5 h / 60 °C / Inert atmosphere
3.1: triethylamine; trifluoroacetic anhydride / 12 h / 0 - 20 °C
4.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol / 12 h / 20 °C
5.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation
6.1: dimethylsulfide borane complex / tetrahydrofuran / 0.5 h / Reflux
6.2: 0.5 h / Reflux
7.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 4 h / 20 °C
With
dimethylsulfide borane complex; hydroxylamine hydrochloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; bromine; sodium acetate; lithium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium hydride / tetrahydrofuran / 5 h / 60 °C / Inert atmosphere
2.1: triethylamine; trifluoroacetic anhydride / 12 h / 0 - 20 °C
3.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol / 12 h / 20 °C
4.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation
5.1: dimethylsulfide borane complex / tetrahydrofuran / 0.5 h / Reflux
5.2: 0.5 h / Reflux
6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 4 h / 20 °C
With
dimethylsulfide borane complex; hydroxylamine hydrochloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; lithium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
