1-2',3',5'-tri-O-benzoyl-β-D-ribopentofuranosyl-5-(ethoxycarbonyl)-4,6-dimethylpyrimidin-2-thione

Base Information

Chemical Name:1-2',3',5'-tri-O-benzoyl-β-D-ribopentofuranosyl-5-(ethoxycarbonyl)-4,6-dimethylpyrimidin-2-thione
CAS No.:1417444-58-6
Molecular Formula:C₃₅H₃₂N₂O₉S
Molecular Weight:656.713
Hs Code.:

Synonyms:1-2',3',5'-tri-O-benzoyl-β-D-ribopentofuranosyl-5-(ethoxycarbonyl)-4,6-dimethylpyrimidin-2-thione

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Chemical Property of 1-2',3',5'-tri-O-benzoyl-β-D-ribopentofuranosyl-5-(ethoxycarbonyl)-4,6-dimethylpyrimidin-2-thione

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Technology Process of 1-2',3',5'-tri-O-benzoyl-β-D-ribopentofuranosyl-5-(ethoxycarbonyl)-4,6-dimethylpyrimidin-2-thione

There total 4 articles about 1-2',3',5'-tri-O-benzoyl-β-D-ribopentofuranosyl-5-(ethoxycarbonyl)-4,6-dimethylpyrimidin-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1257325-74-8
ethyl 4,6-dimethylpyrimidin-2(1H)-thione-5-carboxylate

: 114762-36-6
2,3,5-tri-O-benzoyl-D-ribofuranosyl fluoride

: 1417444-58-6
1-2',3',5'-tri-O-benzoyl-β-D-ribopentofuranosyl-5-(ethoxycarbonyl)-4,6-dimethylpyrimidin-2-thione

Guidance literature:: With boron trifluoride diethyl etherate; In acetonitrile; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2012.11.017

Reference yield:

: 17994-56-8,64612-96-0,123410-61-7
ethyl 4,6-dimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1417444-58-6
1-2',3',5'-tri-O-benzoyl-β-D-ribopentofuranosyl-5-(ethoxycarbonyl)-4,6-dimethylpyrimidin-2-thione

Guidance literature:: Multi-step reaction with 3 steps

1: pyrographite / 5,5-dimethyl-1,3-cyclohexadiene / 140 °C

2: Lawessons reagent / benzene / 3 h / 90 °C / Inert atmosphere

3: boron trifluoride diethyl etherate / acetonitrile / 1 h / 0 °C / Inert atmosphere

With Lawessons reagent; boron trifluoride diethyl etherate; pyrographite; In 5,5-dimethyl-1,3-cyclohexadiene; acetonitrile; benzene;
DOI:10.1016/j.tet.2012.11.017

Reference yield:

: 141-97-9
ethyl acetoacetate

: 1417444-58-6
1-2',3',5'-tri-O-benzoyl-β-D-ribopentofuranosyl-5-(ethoxycarbonyl)-4,6-dimethylpyrimidin-2-thione

Guidance literature:: Multi-step reaction with 4 steps

1: poly phosphate ester / 26 h / 70 °C / Inert atmosphere

2: pyrographite / 5,5-dimethyl-1,3-cyclohexadiene / 140 °C

3: Lawessons reagent / benzene / 3 h / 90 °C / Inert atmosphere

4: boron trifluoride diethyl etherate / acetonitrile / 1 h / 0 °C / Inert atmosphere

With Lawessons reagent; boron trifluoride diethyl etherate; pyrographite; In 5,5-dimethyl-1,3-cyclohexadiene; acetonitrile; benzene;
DOI:10.1016/j.tet.2012.11.017