1-<6-Benzyloxy-3,3-bis(ethoxycarbonyl)-hexyl>-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol

Base Information

• Chemical Name: 1-<6-Benzyloxy-3,3-bis(ethoxycarbonyl)-hexyl>-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol
• CAS No.: 128432-25-7
• Molecular Formula: C₃₀H₃₈N₂O₅
• Molecular Weight: 506.642
• Mol file: 128432-25-7.mol

Synonyms:1-<6-Benzyloxy-3,3-bis(ethoxycarbonyl)-hexyl>-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol

Chemical Property of 1-<6-Benzyloxy-3,3-bis(ethoxycarbonyl)-hexyl>-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<6-Benzyloxy-3,3-bis(ethoxycarbonyl)-hexyl>-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol

There total 2 articles about 1-<6-Benzyloxy-3,3-bis(ethoxycarbonyl)-hexyl>-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tryptamine (61-54-1) + 7-Benzyloxy-4,4-bis(ethoxycarbonyl)heptanal (107704-30-3) → 1-<6-Benzyloxy-3,3-bis(ethoxycarbonyl)-hexyl>-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol (128432-25-7)

Guidance literature:

With acetic acid; for 2h; Ambient temperature;

DOI:10.1016/S0040-4020(01)86686-2

Reference yield:

Ethyl 5-benzyloxy-2-(ethoxycarbonyl)pentanoate (82258-55-7) → 1-<6-Benzyloxy-3,3-bis(ethoxycarbonyl)-hexyl>-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol (128432-25-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Na / 1) ethanol, 5 deg C, 2) 1.5 h, r.t.

2: 80 percent / 80 percent CH₃COOH / 2 h / Ambient temperature

With sodium; acetic acid;

DOI:10.1016/S0040-4020(01)86686-2

Reference yield: 62.0%

1-<6-Benzyloxy-3,3-bis(ethoxycarbonyl)-hexyl>-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol (128432-25-7) → 3-(3-Benzyloxypropyl)-4-oxo-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizin-3-carbonsaeureethylester (107704-31-4)

Guidance literature:

With potassium carbonate; In ethanol; for 90h;

DOI:10.1016/S0040-4020(01)86686-2

upstream raw materials:

tryptamine

7-Benzyloxy-4,4-bis(ethoxycarbonyl)heptanal

Ethyl 5-benzyloxy-2-(ethoxycarbonyl)pentanoate

Downstream raw materials:

3-(3-Benzyloxypropyl)-4-oxo-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizin-3-carbonsaeureethylester

3-(3-Benzyloxypropyl)-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizin-4-on

9-(3-Benzyloxy-propyl)-6,7,8,9,10,11,12,13-octahydro-5H-7,13-diaza-cyclodeca[a]indene-12-carboxylic acid

3-Benzyloxycarbonyl-5-(3-hydroxypropyl)-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>indol-8-carbonsaeuemethylester