{7-[3-(2-hydroxymethyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-3-phenyl-2,3-dihydro-benzofuran-3-yl}-methanol

Base Information

• Chemical Name: {7-[3-(2-hydroxymethyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-3-phenyl-2,3-dihydro-benzofuran-3-yl}-methanol
• CAS No.: 405519-80-4
• Molecular Formula: C₂₉H₂₆N₂O₅
• Molecular Weight: 482.536

Synonyms:{7-[3-(2-hydroxymethyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-3-phenyl-2,3-dihydro-benzofuran-3-yl}-methanol

Chemical Property of {7-[3-(2-hydroxymethyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-3-phenyl-2,3-dihydro-benzofuran-3-yl}-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {7-[3-(2-hydroxymethyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-3-phenyl-2,3-dihydro-benzofuran-3-yl}-methanol

There total 12 articles about {7-[3-(2-hydroxymethyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-3-phenyl-2,3-dihydro-benzofuran-3-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-[3-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-2,3-dihydro-benzofuran-7-yl]-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1-methoxymethyl-1H-indole (405519-79-1) → {7-[3-(2-hydroxymethyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-3-phenyl-2,3-dihydro-benzofuran-3-yl}-methanol (405519-80-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 0.166667h;

DOI:10.1002/1521-3773(20011217)40:24<4705::AID-ANIE4705>3.0.CO;2-D

Reference yield:

2-hydroxybromobenzene (95-56-7) → {7-[3-(2-hydroxymethyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-3-phenyl-2,3-dihydro-benzofuran-3-yl}-methanol (405519-80-4)

Guidance literature:

Multi-step reaction with 9 steps

1: 42 percent / aq. H₂SO₄ / 45 h / Heating

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: Yb(OTf)3 / tetrahydrofuran; H₂O / 24 h / 25 °C

4: 95 percent / imidazole / dimethylformamide / 6 h / 25 °C

5: 95 percent / LiBH₄ / tetrahydrofuran / 4 h / 25 °C

6: 95 percent / 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Heating

7: 70 percent / KOAc / [Pd(dppf)Cl₂]*CH₂Cl₂ / dimethylsulfoxide / 6 h / 90 °C

8: 66 percent / K₂CO₃ / [Pd(dppf)Cl₂]*CH₂Cl₂ / 1,2-dimethoxy-ethane / 8 h / 110 °C

9: 93 percent / TBAF / tetrahydrofuran / 0.17 h / 25 °C

With 1H-imidazole; lithium borohydride; sulfuric acid; tetrabutyl ammonium fluoride; potassium acetate; potassium carbonate; triethylamine; 1,1'-carbonyldiimidazole; ytterbium(III) triflate; [1,1'-bis(diphenylphosphino)-ferrocene]palladium(II) chloride-dichlormethane complex; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1002/1521-3773(20011217)40:24<4705::AID-ANIE4705>3.0.CO;2-D

Reference yield:

MANDELIC ACID (611-71-2,611-72-3,17199-29-0,90-64-2) → {7-[3-(2-hydroxymethyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-3-phenyl-2,3-dihydro-benzofuran-3-yl}-methanol (405519-80-4)

Guidance literature:

Multi-step reaction with 9 steps

1: 42 percent / aq. H₂SO₄ / 45 h / Heating

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: Yb(OTf)3 / tetrahydrofuran; H₂O / 24 h / 25 °C

4: 95 percent / imidazole / dimethylformamide / 6 h / 25 °C

5: 95 percent / LiBH₄ / tetrahydrofuran / 4 h / 25 °C

6: 95 percent / 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Heating

7: 70 percent / KOAc / [Pd(dppf)Cl₂]*CH₂Cl₂ / dimethylsulfoxide / 6 h / 90 °C

8: 66 percent / K₂CO₃ / [Pd(dppf)Cl₂]*CH₂Cl₂ / 1,2-dimethoxy-ethane / 8 h / 110 °C

9: 93 percent / TBAF / tetrahydrofuran / 0.17 h / 25 °C

With 1H-imidazole; lithium borohydride; sulfuric acid; tetrabutyl ammonium fluoride; potassium acetate; potassium carbonate; triethylamine; 1,1'-carbonyldiimidazole; ytterbium(III) triflate; [1,1'-bis(diphenylphosphino)-ferrocene]palladium(II) chloride-dichlormethane complex; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1002/1521-3773(20011217)40:24<4705::AID-ANIE4705>3.0.CO;2-D

upstream raw materials:

4-[3-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-2,3-dihydro-benzofuran-7-yl]-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1-methoxymethyl-1H-indole

2-hydroxybromobenzene

MANDELIC ACID

7-Bromo-3-phenyl-3H-benzofuran-2-one

Downstream raw materials:

C₃₁H₂₁Cl₂N₃O₄

C₃₁H₂₅N₃O₅

C₃₁H₂₇N₃O₅

C₃₀H₂₁N₃O₄

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