(4aR,7aR,9R,10aS)-5-carbomethoxy-1,7-dioxo-1,2,3,4,4a,7a,9,10-tert-butyldiphenylsiloxymethyl-2-tert-butyldiphenylsiloxypentane-8-(tert-butyloxy)pyrrolo[4.5-i]isoquinoline

Base Information

Chemical Name:(4aR,7aR,9R,10aS)-5-carbomethoxy-1,7-dioxo-1,2,3,4,4a,7a,9,10-tert-butyldiphenylsiloxymethyl-2-tert-butyldiphenylsiloxypentane-8-(tert-butyloxy)pyrrolo[4.5-i]isoquinoline
CAS No.:221136-32-9
Molecular Formula:C₅₆H₇₂N₂O₈Si₂
Molecular Weight:957.367
Hs Code.:

(4aR,7aR,9R,10aS)-5-carbomethoxy-1,7-dioxo-1,2,3,4,4a,7a,9,10-tert-butyldiphenylsiloxymethyl-2-tert-butyldiphenylsiloxypentane-8-(tert-butyloxy)pyrrolo[4.5-i]isoquinoline

Synonyms:(4aR,7aR,9R,10aS)-5-carbomethoxy-1,7-dioxo-1,2,3,4,4a,7a,9,10-tert-butyldiphenylsiloxymethyl-2-tert-butyldiphenylsiloxypentane-8-(tert-butyloxy)pyrrolo[4.5-i]isoquinoline

Suppliers and Price of (4aR,7aR,9R,10aS)-5-carbomethoxy-1,7-dioxo-1,2,3,4,4a,7a,9,10-tert-butyldiphenylsiloxymethyl-2-tert-butyldiphenylsiloxypentane-8-(tert-butyloxy)pyrrolo[4.5-i]isoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4aR,7aR,9R,10aS)-5-carbomethoxy-1,7-dioxo-1,2,3,4,4a,7a,9,10-tert-butyldiphenylsiloxymethyl-2-tert-butyldiphenylsiloxypentane-8-(tert-butyloxy)pyrrolo[4.5-i]isoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4aR,7aR,9R,10aS)-5-carbomethoxy-1,7-dioxo-1,2,3,4,4a,7a,9,10-tert-butyldiphenylsiloxymethyl-2-tert-butyldiphenylsiloxypentane-8-(tert-butyloxy)pyrrolo[4.5-i]isoquinoline

There total 8 articles about (4aR,7aR,9R,10aS)-5-carbomethoxy-1,7-dioxo-1,2,3,4,4a,7a,9,10-tert-butyldiphenylsiloxymethyl-2-tert-butyldiphenylsiloxypentane-8-(tert-butyloxy)pyrrolo[4.5-i]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (5R)-5-(tert-butyldiphenylsilanyloxymethyl)-2-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester 3-sodium carboxylate

: 221136-32-9
(4aR,7aR,9R,10aS)-5-carbomethoxy-1,7-dioxo-1,2,3,4,4a,7a,9,10-tert-butyldiphenylsiloxymethyl-2-tert-butyldiphenylsiloxypentane-8-(tert-butyloxy)pyrrolo[4.5-i]isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl chloride / benzene / 0.25 h / 0 °C

1.2: 79 percent / Et₃N / CH₂Cl₂ / 0 °C

2.1: 68 percent / tetrakistriphenylphosphine palladium / toluene / 30 h / Heating

3.1: 63 percent / CrO₃; 3,5-dimethylpyrazole / CH₂Cl₂ / 48 h / -18 °C

With 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; oxalyl dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; toluene; benzene;
DOI:10.1021/ja0202964

Reference yield:

: 221136-22-7
(2S)-4-{(Z-4-bromo-4-methoxycarbonylbut-3-enyl)-[5-(tert-butyldiphenylsilanyloxy)pentyl]carbamoyl}-2-(tert-butyldiphenylsilanyloxymethyl)-2,3-dihydropyrrole-1-carboxylic acid tert-butyl ester

: 221136-32-9
(4aR,7aR,9R,10aS)-5-carbomethoxy-1,7-dioxo-1,2,3,4,4a,7a,9,10-tert-butyldiphenylsiloxymethyl-2-tert-butyldiphenylsiloxypentane-8-(tert-butyloxy)pyrrolo[4.5-i]isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / tetrakistriphenylphosphine palladium / toluene / 30 h / Heating

2: 63 percent / CrO₃; 3,5-dimethylpyrazole / CH₂Cl₂ / 48 h / -18 °C

With 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; toluene;
DOI:10.1021/ja0202964

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 221136-32-9
(4aR,7aR,9R,10aS)-5-carbomethoxy-1,7-dioxo-1,2,3,4,4a,7a,9,10-tert-butyldiphenylsiloxymethyl-2-tert-butyldiphenylsiloxypentane-8-(tert-butyloxy)pyrrolo[4.5-i]isoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: 93 percent / DMAP; triethylamine / CH₂Cl₂ / 0 - 20 °C

2.1: hexamethyldisilazane; n-BuLi / tetrahydrofuran; hexane / 0.25 h / -25 °C

2.2: tetrahydrofuran; hexane / -78 °C

2.3: NaBH₄ / tetrahydrofuran; ethanol; hexane / 0.33 h / 0 °C

3.1: oxalyl chloride / benzene / 0.25 h / 0 °C

3.2: 79 percent / Et₃N / CH₂Cl₂ / 0 °C

4.1: 68 percent / tetrakistriphenylphosphine palladium / toluene / 30 h / Heating

5.1: 63 percent / CrO₃; 3,5-dimethylpyrazole / CH₂Cl₂ / 48 h / -18 °C

With 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; dmap; n-butyllithium; oxalyl dichloride; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; toluene; benzene;
DOI:10.1021/ja0202964