(2S,4S)-2-[(5-carbamoyl)-1,2,4-oxadiazol-3-ylmethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

Base Information

Chemical Name:(2S,4S)-2-[(5-carbamoyl)-1,2,4-oxadiazol-3-ylmethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine
CAS No.:675836-68-7
Molecular Formula:C₃₁H₃₀N₄O₄S
Molecular Weight:554.67
Hs Code.:

Synonyms:(2S,4S)-2-[(5-carbamoyl)-1,2,4-oxadiazol-3-ylmethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

Suppliers and Price of (2S,4S)-2-[(5-carbamoyl)-1,2,4-oxadiazol-3-ylmethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (2S,4S)-2-[(5-carbamoyl)-1,2,4-oxadiazol-3-ylmethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4S)-2-[(5-carbamoyl)-1,2,4-oxadiazol-3-ylmethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

There total 7 articles about (2S,4S)-2-[(5-carbamoyl)-1,2,4-oxadiazol-3-ylmethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.1%

: 675836-65-4
(2S,4S)-2-[(5-ethoxycarbonyl)-1,2,4-oxadiazol-3-ylmethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

: 675836-68-7
(2S,4S)-2-[(5-carbamoyl)-1,2,4-oxadiazol-3-ylmethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

Guidance literature:: With ammonium hydroxide; In ethanol; at 60 ℃; for 3h;
DOI:10.1002/ardp.200300768

Reference yield:

: 3695-77-0
triphenylmethanethiol

: 675836-68-7
(2S,4S)-2-[(5-carbamoyl)-1,2,4-oxadiazol-3-ylmethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH / dimethylformamide / 1 h / 20 °C

1.2: 82.5 percent / dimethylformamide / 3 h / 20 °C

2.1: 78.5 percent / LiBH₄ / tetrahydrofuran / 25 h / 20 °C

3.1: 94.8 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

4.1: 89.1 percent / dimethylsulfoxide / 5 h / 75 °C

5.1: hydroxylamine hydrochloride; Na₂CO₃ / ethanol; H₂O / 20 h / 60 °C

6.1: 22.3 g / tetrahydrofuran / 2 h / Heating

7.1: 78.1 percent / aq. NH₄OH / ethanol / 3 h / 60 °C

With ammonium hydroxide; lithium borohydride; hydroxylamine hydrochloride; sodium hydride; sodium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/ardp.200300768

Reference yield:

: 126438-17-3
(2S,4R)-1-allyloxycarbonyl-4-methanesulfonyloxy-2-methoxycarbonylpyrrolidine

: 675836-68-7
(2S,4S)-2-[(5-carbamoyl)-1,2,4-oxadiazol-3-ylmethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH / dimethylformamide / 1 h / 20 °C

1.2: 82.5 percent / dimethylformamide / 3 h / 20 °C

2.1: 78.5 percent / LiBH₄ / tetrahydrofuran / 25 h / 20 °C

3.1: 94.8 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

4.1: 89.1 percent / dimethylsulfoxide / 5 h / 75 °C

5.1: hydroxylamine hydrochloride; Na₂CO₃ / ethanol; H₂O / 20 h / 60 °C

6.1: 22.3 g / tetrahydrofuran / 2 h / Heating

7.1: 78.1 percent / aq. NH₄OH / ethanol / 3 h / 60 °C

With ammonium hydroxide; lithium borohydride; hydroxylamine hydrochloride; sodium hydride; sodium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/ardp.200300768