2-O-allyl-3-[5-(hydroxymethyl)-1-phenylpyrazol-3-yl]quinoxaline

Base Information

• Chemical Name: 2-O-allyl-3-[5-(hydroxymethyl)-1-phenylpyrazol-3-yl]quinoxaline
• CAS No.: 641629-39-2
• Molecular Formula: C₂₁H₁₈N₄O₂
• Molecular Weight: 358.4
• Mol file: 641629-39-2.mol

Synonyms:2-O-allyl-3-[5-(hydroxymethyl)-1-phenylpyrazol-3-yl]quinoxaline

Chemical Property of 2-O-allyl-3-[5-(hydroxymethyl)-1-phenylpyrazol-3-yl]quinoxaline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-O-allyl-3-[5-(hydroxymethyl)-1-phenylpyrazol-3-yl]quinoxaline

There total 9 articles about 2-O-allyl-3-[5-(hydroxymethyl)-1-phenylpyrazol-3-yl]quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3-<5-(hydroxymethyl)-1-phenylpyrazol-3-yl>quinoxalin-2-one (66895-45-2) + allyl bromide (106-95-6) → 2-O-allyl-3-[5-(hydroxymethyl)-1-phenylpyrazol-3-yl]quinoxaline (641629-39-2) + 1-N-allyl-3-[5-(hydroxymethyl)-1-phenylpyrazol-3-yl]quinoxalin-2-one (641629-40-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 0.116667h; microwave irradiation;

DOI:10.1080/07328300701252359

Reference yield: 41.0%

allyl bromide (106-95-6) + 3-[1-(phenylhydrazono)-L-threo-2,3,4-trihydroxybut-1-yl]quinoxalin-2(1H)one (66895-34-9) → 2-O-allyl-3-[5-(hydroxymethyl)-1-phenylpyrazol-3-yl]quinoxaline (641629-39-2) + 1-N-allyl-3-[5-(hydroxymethyl)-1-phenylpyrazol-3-yl]quinoxalin-2-one (641629-40-5) + 1-N-allyl-3-[1-(phenylhydrazono)-L-threo-2,3,4-trihydroxybut-1-yl]quinoxalin-2-one

Guidance literature:

3-[1-(phenylhydrazono)-L-threo-2,3,4-trihydroxybut-1-yl]quinoxalin-2(1H)one; With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

allyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1016/S0008-6215(03)00376-8

Reference yield:

1,2-diamino-benzene (95-54-5) → 2-O-allyl-3-[5-(hydroxymethyl)-1-phenylpyrazol-3-yl]quinoxaline (641629-39-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 86 percent / acetic acid / ethanol; H₂O / 0.07 h / microwave irradiation

2.1: 88 percent / bentonite / 0.12 h / microwave irradiation

3.1: bentonite; sodium hydroxide / ethanol; H₂O / 0.03 h / microwave irradiation

3.2: 92 percent / acetic acid / ethanol; H₂O

4.1: 30 percent / potassium carbonate / dimethylformamide / 0.12 h / microwave irradiation

With sodium hydroxide; potassium carbonate; acetic acid; bentonite; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1080/07328300701252359

upstream raw materials:

allyl bromide

3-[1-(phenylhydrazono)-L-threo-2,3,4-trihydroxybut-1-yl]quinoxalin-2(1H)one

3-<5-(hydroxymethyl)-1-phenylpyrazol-3-yl>quinoxalin-2-one

3-<5-(Acetoxymethyl)-1-phenylpyrazol-3-yl>quinoxalin-2(1H)-one