Technology Process of 5,6-trans-1α-Acetoxyvitamin D3
There total 5 articles about 5,6-trans-1α-Acetoxyvitamin D3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: pyridine / 24 h / 5 °C
2: 60 mg / NaHCO3 / 8 h / 55 °C
3: 50 percent / tert butyl hydroperoxide, SeO2 / CH2Cl2 / 1.15 h / Ambient temperature
4: 32 mg / pyridine / 2 h / 55 °C
5: 2) saturated NaHCO3 / formic acid / 1) dry THF, 15 min, 55 deg C
With
tert.-butylhydroperoxide; selenium(IV) oxide; sodium hydrogencarbonate;
formic acid;
In
pyridine; dichloromethane;
DOI:10.1021/jo01304a022
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 50 percent / tert butyl hydroperoxide, SeO2 / CH2Cl2 / 1.15 h / Ambient temperature
2: 32 mg / pyridine / 2 h / 55 °C
3: 2) saturated NaHCO3 / formic acid / 1) dry THF, 15 min, 55 deg C
With
tert.-butylhydroperoxide; selenium(IV) oxide; sodium hydrogencarbonate;
formic acid;
In
pyridine; dichloromethane;
DOI:10.1021/jo01304a022
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 32 mg / pyridine / 2 h / 55 °C
2: 2) saturated NaHCO3 / formic acid / 1) dry THF, 15 min, 55 deg C
With
sodium hydrogencarbonate;
formic acid;
In
pyridine;
DOI:10.1021/jo01304a022
