LeterMovir

Base Information

• Chemical Name: LeterMovir
• CAS No.: 917389-32-3
• Molecular Formula: C₂₉H₂₈F₄N₄O₄
• Molecular Weight: 572.559
• Mol file: 917389-32-3.mol

Synonyms:(S)-2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)-phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid

Chemical Property of LeterMovir

Chemical Property:

• Boiling Point: 706.5±70.0 °C(Predicted)
• PKA: 4.00±0.10(Predicted)
• Density: 1.37±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Solubility.: ≥57.3 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

Purity/Quality:

98%,99%, ^*data from raw suppliers

Letermovir ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Letermovir acts as an orally or i.v administered cytomegalovirus terminus complex inhibitor, antiviral agent, used in the treatment of CMV infection which is prevalent in those with immunocompromised systems.

Technology Process of LeterMovir

There total 57 articles about LeterMovir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.4%

(2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]succinic acid {(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-(2-methoxy-5-(trifluormethyl)phenyl)-3,4-dihydroquinazolin-4-yl}acetic acid methyl ester (917389-30-1) → (S)-2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)-phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid (917389-32-3)

Guidance literature:

With water; sodium hydrogencarbonate; sodium hydroxide; In tert-butyl methyl ether; Reflux; Large scale;

Reference yield: 96.4%

(2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]succinic acid-{(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazine-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazoline-4-yl}methyl acetate → (S)-2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)-phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid (917389-32-3)

Guidance literature:

(2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]succinic acid-{(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazine-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazoline-4-yl}methyl acetate; With sodium hydrogencarbonate; In tert-butyl methyl ether; water; Large scale;

With water; sodium hydroxide; In tert-butyl methyl ether; Reflux; Large scale;

Reference yield: 94.0%

(S)-methyl 2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetate (2S,3S)-2,3-bis((4-methylbenzoyl)oxy)succinate ethyl acetate → (S)-2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)-phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid (917389-32-3)

Guidance literature:

(S)-methyl 2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetate (2S,3S)-2,3-bis((4-methylbenzoyl)oxy)succinate ethyl acetate; With disodium hydrogenphosphate; tert-butyl methyl ether; In water; for 2h;

With sodium hydroxide; In water; at 60 ℃; for 5h; Inert atmosphere;

DOI:10.1021/acs.oprd.6b00076

upstream raw materials:

(2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]succinic acid {(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-(2-methoxy-5-(trifluormethyl)phenyl)-3,4-dihydroquinazolin-4-yl}acetic acid methyl ester

(R)-methyl 2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetate

methyl 2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-4-yl)acetate

2-Fluoroaniline

Refernces

• 1、 Wang, Pu-Sheng,Shen, Meng-Lan,Wang, Tian-Ci,Lin, Hua-Chen,Gong, Liu-Zhu. "Access to Chiral Hydropyrimidines through Palladium-Catalyzed Asymmetric Allylic C?H Amination". . p. 16032 - 16036. Retrieved 2017/11/23.
• 2、 Humphrey, Guy R.,Dalby, Stephen M.,Andreani, Teresa,Xiang, Bangping,Luzung, Michael R.,Song, Zhiguo Jake,Shevlin, Michael,Christensen, Melodie,Belyk, Kevin M.,Tschaen, David M.. "Asymmetric synthesis of letermovir using a novel phase-Transfer-catalyzed aza-michael reaction". . p. 1097 - 1103. Retrieved 2017/01/16.