(3R)-tert-butyl 3-ethyl-3-[(1S)-2-nitro-1-phenylethyl]-2-oxoindoline-1-carboxylate

Base Information

• Chemical Name: (3R)-tert-butyl 3-ethyl-3-[(1S)-2-nitro-1-phenylethyl]-2-oxoindoline-1-carboxylate
• CAS No.: 1168139-71-6
• Molecular Formula: C₂₃H₂₆N₂O₅
• Molecular Weight: 410.47
• Mol file: 1168139-71-6.mol

Synonyms:(3R)-tert-butyl 3-ethyl-3-[(1S)-2-nitro-1-phenylethyl]-2-oxoindoline-1-carboxylate

Chemical Property of (3R)-tert-butyl 3-ethyl-3-[(1S)-2-nitro-1-phenylethyl]-2-oxoindoline-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R)-tert-butyl 3-ethyl-3-[(1S)-2-nitro-1-phenylethyl]-2-oxoindoline-1-carboxylate

There total 2 articles about (3R)-tert-butyl 3-ethyl-3-[(1S)-2-nitro-1-phenylethyl]-2-oxoindoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-ethyl-2-oxoindoline-1-carboxylate (862907-08-2) + (2-nitroethenyl)benzene (102-96-5) → (3R)-tert-butyl 3-ethyl-3-[(1S)-2-nitro-1-phenylethyl]-2-oxoindoline-1-carboxylate (1168139-71-6) + tert-butyl 3-ethyl-3-[2-nitro-1-phenylethyl]-2-oxoindoline-1-carboxylate + (3S)-tert-butyl 3-ethyl-3-[(1R)-2-nitro-1-phenylethyl]-2-oxoindoline-1-carboxylate (1394920-56-9)

Guidance literature:

With quinine; In chloroform; at -20 ℃; for 12h; optical yield given as %ee; enantioselective reaction;

DOI:10.1016/j.tetasy.2012.06.018

Reference yield:

tert-butyl 3-ethyl-2-oxoindoline-1-carboxylate (862907-08-2) + nitrostyrene (5153-67-3) → (3R)-tert-butyl 3-ethyl-3-[(1S)-2-nitro-1-phenylethyl]-2-oxoindoline-1-carboxylate (1168139-71-6) + (3S)-tert-butyl 3-ethyl-3-[(1R)-2-nitro-1-phenylethyl]-2-oxoindoline-1-carboxylate (1394920-56-9) + C23H26N2O5

Guidance literature:

With C₇₂H₇₂N₆NiO₄⁽²⁺⁾*2BF₄^(1-); In 1,2-dichloro-ethane; at 80 ℃; for 20h; Overall yield = 95 %; Overall yield = 96 %Spectr.; stereoselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201502930

upstream raw materials:

tert-butyl 3-ethyl-2-oxoindoline-1-carboxylate

(2-nitroethenyl)benzene

nitrostyrene