(4R,5R)-4,5-bis[(1S)-1-methylprop-2-en-1-yl]-1,3-bis[(1S)-1-phenylethyl]-1,3,2-diazaphospholidine 2-oxide

Base Information

• Chemical Name: (4R,5R)-4,5-bis[(1S)-1-methylprop-2-en-1-yl]-1,3-bis[(1S)-1-phenylethyl]-1,3,2-diazaphospholidine 2-oxide
• CAS No.: 880764-42-1
• Molecular Formula: C₂₆H₃₅N₂OP
• Molecular Weight: 422.55
• Mol file: 880764-42-1.mol

Synonyms:(4R,5R)-4,5-bis[(1S)-1-methylprop-2-en-1-yl]-1,3-bis[(1S)-1-phenylethyl]-1,3,2-diazaphospholidine 2-oxide

Chemical Property of (4R,5R)-4,5-bis[(1S)-1-methylprop-2-en-1-yl]-1,3-bis[(1S)-1-phenylethyl]-1,3,2-diazaphospholidine 2-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5R)-4,5-bis[(1S)-1-methylprop-2-en-1-yl]-1,3-bis[(1S)-1-phenylethyl]-1,3,2-diazaphospholidine 2-oxide

There total 2 articles about (4R,5R)-4,5-bis[(1S)-1-methylprop-2-en-1-yl]-1,3-bis[(1S)-1-phenylethyl]-1,3,2-diazaphospholidine 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(3S,4R,5R,6S)-3,6-Dimethyl-N,N'-bis-((S)-1-phenyl-ethyl)-octa-1,7-diene-4,5-diamine (880517-58-8) → (4R,5R)-4,5-bis[(1S)-1-methylprop-2-en-1-yl]-1,3-bis[(1S)-1-phenylethyl]-1,3,2-diazaphospholidine 2-oxide (880764-42-1)

Guidance literature:

With dmap; triethylamine; phosphorus trichloride; In dichloromethane; for 3h; Heating;

DOI:10.1055/s-2005-918515

Reference yield:

(3S,4R,5R)-3,6-Dimethyl-N,N'-bis-((S)-1-phenyl-ethyl)-octa-1,7-diene-4,5-diamine; compound with GENERIC INORGANIC NEUTRAL COMPONENT → (4R,5R)-4,5-bis[(1S)-1-methylprop-2-en-1-yl]-1,3-bis[(1S)-1-phenylethyl]-1,3,2-diazaphospholidine 2-oxide (880764-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 37 percent / PhC=Ru<[(Mes)CH₂CH₂(Mes)]CH>PCy₃Cl₂ / CH₂Cl₂ / 3 h / 40 °C

2: 93 percent / PCl₃; DMAP; Et₃N / CH₂Cl₂ / 3 h / Heating

With dmap; triethylamine; phosphorus trichloride; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane;

DOI:10.1055/s-2005-918515

Reference yield:

(4R,5R)-4,5-bis[(1S)-1-methylprop-2-en-1-yl]-1,3-bis[(1S)-1-phenylethyl]-1,3,2-diazaphospholidine 2-oxide (880764-42-1) → (3aR,4S,7S,7aR)-4,7-Dimethyl-1,3-bis-((S)-1-phenyl-ethyl)-1,3,3a,4,7,7a-hexahydro-benzo[1,3,2]diazaphosphole 2-oxide

Guidance literature:

tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 40 ℃; for 3h;

DOI:10.1055/s-2005-918515

upstream raw materials:

(3S,4R,5R,6S)-3,6-Dimethyl-N,N'-bis-((S)-1-phenyl-ethyl)-octa-1,7-diene-4,5-diamine

Downstream raw materials:

(1R,2R,3S,6S)-3,6-dimethyl-N,N'-bis[(1S)-1-phenylethyl]cyclohex-4-ene-1,2-diamine