(4S,5R)-2-chloro-4-methyl-3-(2-methylpropyl)-5-phenyl-1,3,2-oxazaphospholidine

Base Information

Chemical Name:(4S,5R)-2-chloro-4-methyl-3-(2-methylpropyl)-5-phenyl-1,3,2-oxazaphospholidine
CAS No.:140189-32-8
Molecular Formula:C₁₃H₁₉ClNOP
Molecular Weight:271.727
Hs Code.:

Synonyms:(4S,5R)-2-chloro-4-methyl-3-(2-methylpropyl)-5-phenyl-1,3,2-oxazaphospholidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5R)-2-chloro-4-methyl-3-(2-methylpropyl)-5-phenyl-1,3,2-oxazaphospholidine

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Technology Process of (4S,5R)-2-chloro-4-methyl-3-(2-methylpropyl)-5-phenyl-1,3,2-oxazaphospholidine

There total 7 articles about (4S,5R)-2-chloro-4-methyl-3-(2-methylpropyl)-5-phenyl-1,3,2-oxazaphospholidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 46408-28-0
(-)-(1R,2S)-2-<(2-methylpropyl)amino>-1-phenylpropanol

: 140189-32-8
(4S,5R)-2-chloro-4-methyl-3-(2-methylpropyl)-5-phenyl-1,3,2-oxazaphospholidine

Guidance literature:: With triethylamine; phosphorus trichloride; In dichloromethane; for 1h; Heating;
DOI:10.1002/hlca.19910740605

Reference yield: 14.0%

: 6390-69-8
3,3',5,5'-tetra(tert-butyl)biphenyl-2,2'-diol

: 140385-49-5
(4R,5S)-2-chloro-4-methyl-3-(2-methylpropyl)-5-phenyl-1,3,2-oxazaphospholidine

: 140385-50-8
(4R,4'R,5S,5'S)-4,4'-dimethyl-3,3'-bis(2-methylpropyl)-5,5'-diphenyl-2,2'-<<3,3',5,5'-tetrakis(1,1-dimethylethyl)-1,1'-biphenyl-2,2'-diyl>bis(oxy)>bis<1,3,2-oxazaphospholidine>

: 140189-32-8
(4S,5R)-2-chloro-4-methyl-3-(2-methylpropyl)-5-phenyl-1,3,2-oxazaphospholidine

Guidance literature:: 3,3',5,5'-tetra(tert-butyl)biphenyl-2,2'-diol; With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; at 30 ℃; for 1h; Inert atmosphere; Schlenk technique;

(4R,5S)-2-chloro-4-methyl-3-(2-methylpropyl)-5-phenyl-1,3,2-oxazaphospholidine; In tetrahydrofuran; diethyl ether; hexane; at 20 ℃; for 40h; Inert atmosphere; Schlenk technique;
DOI:10.1002/hlca.19910740605

Reference yield:

: 37577-28-9,58550-13-3,757124-50-8
(1S,2R)-(+)-norphedrine

: 140189-32-8
(4S,5R)-2-chloro-4-methyl-3-(2-methylpropyl)-5-phenyl-1,3,2-oxazaphospholidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 0.25 h / Inert atmosphere; Schlenk technique; Reflux

2.1: sodium tetrahydroborate / methanol; water / 1.25 h / 20 °C / Inert atmosphere; Schlenk technique

3.1: phosphorus trichloride; triethylamine / dichloromethane / 1 h / Inert atmosphere; Schlenk technique; Reflux

4.1: n-butyllithium / diethyl ether; hexane; tetrahydrofuran / 1 h / 30 °C / Inert atmosphere; Schlenk technique

4.2: 40 h / 20 °C / Inert atmosphere; Schlenk technique

With sodium tetrahydroborate; n-butyllithium; triethylamine; phosphorus trichloride; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; toluene;
DOI:10.1002/hlca.19910740605