Chlorprothixene

Base Information

• Chemical Name: Chlorprothixene
• CAS No.: 113-59-7
• Molecular Formula: C18H18ClNS
• Molecular Weight: 315.867
• Hs Code.: 2932999099
• NSC Number: 758399,169899,78193,78192,64084,56379,56378
• ChEMBL ID: CHEMBL1406274
• Mol file: 113-59-7.mol

Synonyms:1-Propanamine,3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-, (Z)-;Thioxanthene-D9,g-propylamine, 2-chloro-N,N-dimethyl-, (Z)-(6CI,7CI,8CI);CPT;CPX;Chlorprothixene;Chlorprotixen;Chlorprotixene;Chlothixen;Iaractan;MK 184;Paxyl;Ro 4-0403;Tactaran;Taractan;Tarasan;Traquilan;Trictal;Truxil;Vetacalm;cis-Chlorprothixene;(3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine;(Z)-2-Chloro-9-(3'-dimethylaminopropylidene)thioxanthene;(Z)-2-Chloro-N,N-dimethylthioxanthene-D9,g-propylamine;1-Propanamine, 3- (2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-, (Z)-;1-propanamine, 3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-, (3Z)-;Chlorprothixene;Tarasan;Taractan;

Chemical Property of Chlorprothixene

Chemical Property:

• Vapor Pressure: 9.06E-08mmHg at 25°C
• Melting Point: 97-98°
• Refractive Index: 1.6000 (estimate)
• Boiling Point: 435 °C at 760 mmHg
• PKA: pKa 8.4(H2O) (Uncertain)
• Flash Point: 216.9 °C
• PSA: 28.54000
• Density: 1.255 g/cm³
• LogP: 5.18800
• Storage Temp.: -20°C
• Water Solubility.: 385.8ug/L(22.5 oC)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 351.0615262
• Heavy Atom Count: 22
• Complexity: 381

Purity/Quality:

99% ^*data from raw suppliers

CPOX ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCC=C1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl
• Isomeric SMILES: CN(C)CC/C=C/1\C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl
• Description: In 2002, the American Association of Poison Control Centers’ Toxic Exposure Surveillance System reported 5224 human exposures to phenothiazines, thioxanthenes, and other neuroleptic medications; 3691 were in adults and 808 in children. Unintentional and intentional exposures accounted for 43.7 and 47.8%, respectively. There were 417 (8.0%) adverse drug reactions reported. Thioxanthenes are chemical compounds in which the oxygen atom in xanthene is replaced with a sulfur atom. They are also related to phenothiazines. Several derivatives are used as typical antipsychotics in the treatment of schizophrenia and other psychoses. The thioxanthenes, as a class, are closely related chemically to the phenothiazines. The major structural difference is that the nitrogen at position 10 in the phenothiazines is replaced by a carbon atom with a double bond to the side chain, as shown in the chemical structure of flupenthixol, which has a double-bonded carbon in the number 10 position. Clopenthixol is a typical antipsychotic drug of the thioxanthenes class and a racemic mixture of cis and trans isomers. Zuclopenthixol, the pure cis isomer, has been much more widely used. Both drugs are equally effective as antipsychotics and have similar adverse effect profiles, but clopenthixol is half as active on a milligram-to-milligram basis and appears to produce more sedation in comparison.
• Uses: muscle relaxant (skeletal) Chlorprothixene has an antipsychotic and sedative action. It has expressed antiemetic activity. It is used in various psychoses, schizophrenia, reactive and neurotic depression with prevalent anxious symptomatology, and in conditions of excitement associated with fear and stress. It may be used in small doses as a sedative agent in neurosis. Thioxanthenes are used as neuroleptic agents, antipsychotics, and major tranquilizers in the treatment of psychosis, including schizophrenia, senile psychosis, pathological jealousy, and borderline personality disorder. Other uses include the treatment of pain, postoperative neuralgia, sedation, anxiety neurosis, childhood behavior problems, and depression. The maximum therapeutic daily oral dose for chlorprothixene, flupenthixol, and thiothixene is 600, 224, and 60 mg, respectively; the maximum intramuscular doses are 200 mg day-1, 100 mg weekly, and 30 mg day-1, respectively. Some thioxanthenes and thioxanthenones have shown signs of possible human therapeutic potential against tumors in mice and in vitro assays, and some thioxanthenes have been shown to have cytotoxic and antimicrobial activities. Chlorprothixene is primarily indicated in conditions such as agitation, mania, psychosis, schizophrenia, and can also be given in adjunctive therapy as an alternative drug of choice for anxiety and herpetic neuralgia. Flupenthixol (HCl and decanoate) is primarily indicated in conditions such as depression, muscle spasms of varied etiology, pain, personality disorder, postoperative nausea and vomiting, psychosis, relief of discomfort in mild urinary tract infections, and schizophrenia. Flupenthixol is also seen to possess powerful antibacterial activity both in vitro and in vivo in mouse experiments. It is bacteriostatic in vitro both against gram-positive and gram-negative bacteria. Thiothixene is used in the management of schizophrenia. It has not been evaluated in the management of behavioral complications in patients with mental retardation. Zuclopenthixol is primarily indicated in conditions such as dementia, to enhance permeation of subcutaneous or intramuscular injections, labyrinthine disorders, prolactinoma, psychosis, schizophrenia, and second trimester abortion. It is also used in the treatment of acute bipolar mania.
• Therapeutic Function: Tranquilizer

Technology Process of Chlorprothixene

There total 1 articles about Chlorprothixene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Chlorprothixene hydrochloride → chlorprothixene (113-59-7)

Guidance literature:

With sodium hydroxide; In water;

DOI:10.1111/j.1751-1097.2009.00584.x

Reference yield: 90.0%

2-(2-methylphenyl)pyridine (10273-89-9) + chlorprothixene (113-59-7) → C30H28N2S

Guidance literature:

With C₁₇H₂₄N₅Ru⁽¹⁺⁾*F₆P^(1-); potassium acetate; potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 35 ℃; for 48h; Inert atmosphere;

DOI:10.1038/s41557-018-0062-3

Refernces