ethyl 4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyrate

Base Information

Chemical Name:ethyl 4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyrate
CAS No.:190276-52-9
Molecular Formula:C₃₄H₃₄N₂O₅S
Molecular Weight:582.72
Hs Code.:

Synonyms:ethyl 4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyrate

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Chemical Property of ethyl 4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyrate

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Technology Process of ethyl 4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyrate

There total 8 articles about ethyl 4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.8%

: 2969-81-5
Ethyl 4-bromobutyrate

: 190276-13-2
biphenyl-2-carboxylic acid [2-hydroxy-4-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-phenyl]-amide

: 190276-52-9
ethyl 4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyrate

Guidance literature:: With potassium carbonate; potassium iodide; In acetone; for 12h; Heating;
DOI:10.1021/jm030287l

Reference yield:

: 5081-36-7
3-methoxy-4-nitrobenzoic acid

: 190276-52-9
ethyl 4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyrate

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / CHCl₃ / Heating

2: Et₃N / CHCl₃ / 20 °C

3: H₂ / Pd/C

4: Et₃N / 20 °C

5: BBr₃

6: 73.8 percent / K₂CO₃; KI / acetone / 12 h / Heating

With thionyl chloride; hydrogen; boron tribromide; potassium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In chloroform; acetone;
DOI:10.1021/jm030287l

Reference yield:

: 67579-92-4
3-methoxy-4-nitrobenzoic acid chloride

: 190276-52-9
ethyl 4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyrate

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CHCl₃ / 20 °C

2: H₂ / Pd/C

3: Et₃N / 20 °C

4: BBr₃

5: 73.8 percent / K₂CO₃; KI / acetone / 12 h / Heating

With hydrogen; boron tribromide; potassium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In chloroform; acetone;
DOI:10.1021/jm030287l