ethyl 3-(5-chloro-2-nitrobenzoyl)-1-cyclobutanecarbonyl-Δ²-pyrazoline-5-carboxylate

Base Information

• Chemical Name: ethyl 3-(5-chloro-2-nitrobenzoyl)-1-cyclobutanecarbonyl-Δ²-pyrazoline-5-carboxylate
• CAS No.: 710300-62-2
• Molecular Formula: C₁₈H₁₈ClN₃O₆
• Molecular Weight: 407.81

Synonyms:ethyl 3-(5-chloro-2-nitrobenzoyl)-1-cyclobutanecarbonyl-Δ²-pyrazoline-5-carboxylate

Chemical Property of ethyl 3-(5-chloro-2-nitrobenzoyl)-1-cyclobutanecarbonyl-Δ²-pyrazoline-5-carboxylate

Chemical Property:

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Technology Process of ethyl 3-(5-chloro-2-nitrobenzoyl)-1-cyclobutanecarbonyl-Δ²-pyrazoline-5-carboxylate

There total 2 articles about ethyl 3-(5-chloro-2-nitrobenzoyl)-1-cyclobutanecarbonyl-Δ²-pyrazoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Cyclobutanecarbonyl chloride (5006-22-4) + ethyl 3-(5-chloro-2-nitrobenzoyl)-Δ2-pyrazoline-5-carboxylate (710300-10-0) → ethyl 3-(5-chloro-2-nitrobenzoyl)-1-cyclobutanecarbonyl-Δ2-pyrazoline-5-carboxylate (710300-62-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.tet.2004.03.013

Reference yield:

5-chloro-2-nitrophenyl vinyl ketone (710300-01-9) → ethyl 3-(5-chloro-2-nitrobenzoyl)-1-cyclobutanecarbonyl-Δ2-pyrazoline-5-carboxylate (710300-62-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / pyridine / acetonitrile / 10 h

2: 98 percent / triethylamine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2004.03.013

Reference yield: 96.0%

ethyl 3-(5-chloro-2-nitrobenzoyl)-1-cyclobutanecarbonyl-Δ2-pyrazoline-5-carboxylate (710300-62-2) → ethyl 3-(2-amino-5-chlorobenzoyl)-1-cyclobutanecarbonyl-Δ2-pyrazoline-5-carboxylate

Guidance literature:

With iron; iron(II) sulfate; In water; for 3h; Heating;

DOI:10.1016/j.tet.2004.03.013

upstream raw materials:

Cyclobutanecarbonyl chloride

ethyl 3-(5-chloro-2-nitrobenzoyl)-Δ²-pyrazoline-5-carboxylate

5-chloro-2-nitrophenyl vinyl ketone

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