C₃₉H₄₇NO₆S

Base Information

• Chemical Name: C₃₉H₄₇NO₆S
• CAS No.: 1404078-72-3
• Molecular Formula: C₃₉H₄₇NO₆S
• Molecular Weight: 657.871
• Mol file: 1404078-72-3.mol

Synonyms:C₃₉H₄₇NO₆S

Chemical Property of C₃₉H₄₇NO₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₉H₄₇NO₆S

There total 1 articles about C₃₉H₄₇NO₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

O-(4-methoxybenzyl)-trichloroacetimidate (89238-99-3) + (2R,3R)-(1R,2S)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl-3-hydroxy-2-methylpentanoate → C39H47NO6S (1404078-72-3)

Guidance literature:

With camphor-10-sulfonic acid; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1039/c2ob26256h

Reference yield: 91.0%

C39H47NO6S (1404078-72-3) → (2S,3R)-3-(4-methoxybenzyloxy)-2-methyl pentan-1-ol

Guidance literature:

C₃₉H₄₇NO₆S; With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at -78 - -20 ℃; for 3h;

With sodium chloride; In tetrahydrofuran; hexane; water; at 20 ℃; for 0.5h;

DOI:10.1039/c2ob26256h

Reference yield:

C39H47NO6S (1404078-72-3) → 2-{(2S,3R,4R)-2-(tert-butyldimethylsilyloxy)-4-[(4-methoxybenzyl)oxy]-3-methylhexyl}-4-[(E)-2-iodovinyl]oxazole (1404078-83-6)

Guidance literature:

Multi-step reaction with 12 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 3 h / -78 - -20 °C

1.2: 0.5 h / 20 °C

2.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

3.1: titanium tetrachloride / dichloromethane / 0.33 h / -50 °C

3.2: 2 h / -40 °C

3.3: 2 h / -78 °C

4.1: 2,6-dimethylpyridine / dichloromethane / 3 h / -78 - 20 °C

5.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 3 h / 0 - 20 °C

6.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C

6.2: 72 h / 20 °C

7.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / -78 °C

8.1: copper(ll) bromide; hexamethylenetetramine; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 2 h / 20 °C

9.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.75 h / -78 °C

10.1: potassium carbonate / methanol / 0 - 20 °C

11.1: Schwartz's reagent / tetrahydrofuran / 1 h / 0 °C

11.2: 0.67 h / -78 °C / Darkness

12.1: tert.-butyl lithium / pentane; diethyl ether / 1 h / -78 °C / Inert atmosphere

12.2: 0.25 h / -78 °C

12.3: 3 h / -78 °C

With 2,6-dimethylpyridine; Schwartz's reagent; diethylamino-sulfur trifluoride; hexamethylenetetramine; dihydrogen peroxide; tert.-butyl lithium; titanium tetrachloride; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; Dess-Martin periodane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; copper(ll) bromide; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; toluene; pentane;

DOI:10.1039/c2ob26256h

upstream raw materials:

O-(4-methoxybenzyl)-trichloroacetimidate

Downstream raw materials:

(2S,3R)-3-(4-methoxybenzyloxy)-2-methylpentanal

(3S,4R,5R)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-4-methylheptanoic acid

methyl [2-(2S,3R,4R)-2-(tert-butyldimethylsilyloxy)-[4-(4-methoxybenzyloxy)-3-methylhexyl]]oxazol-4-carboxylate

methyl-[2-(2S,3R,4R)-2-(tert-butyldimethylsilyloxy)-[4-(4-methoxybenzyloxy)-3-methylhexyl]]oxazol-4-carboxylate