2-[5-Methoxy-2-(4-{[2-(4-methoxy-phenoxy)-ethyl]-methyl-amino}-butoxy)-phenyl]-4-methyl-4H-benzo[1,4]thiazin-3-one

Base Information

• Chemical Name: 2-[5-Methoxy-2-(4-{[2-(4-methoxy-phenoxy)-ethyl]-methyl-amino}-butoxy)-phenyl]-4-methyl-4H-benzo[1,4]thiazin-3-one
• CAS No.: 127732-37-0
• Molecular Formula: C₃₀H₃₆N₂O₅S
• Molecular Weight: 536.692

Synonyms:2-[5-Methoxy-2-(4-{[2-(4-methoxy-phenoxy)-ethyl]-methyl-amino}-butoxy)-phenyl]-4-methyl-4H-benzo[1,4]thiazin-3-one

Chemical Property of 2-[5-Methoxy-2-(4-{[2-(4-methoxy-phenoxy)-ethyl]-methyl-amino}-butoxy)-phenyl]-4-methyl-4H-benzo[1,4]thiazin-3-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[5-Methoxy-2-(4-{[2-(4-methoxy-phenoxy)-ethyl]-methyl-amino}-butoxy)-phenyl]-4-methyl-4H-benzo[1,4]thiazin-3-one

There total 2 articles about 2-[5-Methoxy-2-(4-{[2-(4-methoxy-phenoxy)-ethyl]-methyl-amino}-butoxy)-phenyl]-4-methyl-4H-benzo[1,4]thiazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-methoxyphenoxy)-N-methylethan-1-amine (102246-82-2) + 2-[2-(4-Bromo-butoxy)-5-methoxy-phenyl]-4-methyl-4H-benzo[1,4]thiazin-3-one (93848-32-9) → 2-[5-Methoxy-2-(4-{[2-(4-methoxy-phenoxy)-ethyl]-methyl-amino}-butoxy)-phenyl]-4-methyl-4H-benzo[1,4]thiazin-3-one (127732-37-0)

Guidance literature:

With sodium hydrogencarbonate; sodium iodide; In N,N-dimethyl-formamide; at 70 - 80 ℃; for 3h;

DOI:10.1021/jm00169a011

Reference yield:

3,4-Dihydro-2-(2-hydroxy-5-methoxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine (93848-37-4) → 2-[5-Methoxy-2-(4-{[2-(4-methoxy-phenoxy)-ethyl]-methyl-amino}-butoxy)-phenyl]-4-methyl-4H-benzo[1,4]thiazin-3-one (127732-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, RT, 30 min, 2.) RT, 2 h

2: NaHCO₃, NaI / dimethylformamide / 3 h / 70 - 80 °C

With sodium hydride; sodium hydrogencarbonate; sodium iodide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00169a011

Reference yield:

2-[5-Methoxy-2-(4-{[2-(4-methoxy-phenoxy)-ethyl]-methyl-amino}-butoxy)-phenyl]-4-methyl-4H-benzo[1,4]thiazin-3-one (127732-37-0) → tert-butyl 4-(2-aminoethyl)phenylacetate (124499-20-3)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 1.5h; Yield given;

DOI:10.1021/jm00169a015

upstream raw materials:

2-(4-methoxyphenoxy)-N-methylethan-1-amine

2-[2-(4-Bromo-butoxy)-5-methoxy-phenyl]-4-methyl-4H-benzo[1,4]thiazin-3-one

3,4-Dihydro-2-(2-hydroxy-5-methoxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine

Downstream raw materials:

tert-butyl 4-(2-aminoethyl)phenylacetate

(4-{2-[6-Amino-9-((3aR,4R,6S,6aS)-6-ethylcarbamoyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-2-ylamino]-ethyl}-phenyl)-acetic acid tert-butyl ester

(4-{2-[6-Amino-9-((2R,3R,4S,5S)-5-ethylcarbamoyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-ylamino]-ethyl}-phenyl)-acetic acid; hydrochloride

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