3-<2'-(benzyloxycarbonylamino)phenyl>-5-butyl-2-<2-(1,3-dioxolan-2-yl)ethyl>-1,4-dimethylpyrrole

Base Information

Chemical Name:3-<2'-(benzyloxycarbonylamino)phenyl>-5-butyl-2-<2-(1,3-dioxolan-2-yl)ethyl>-1,4-dimethylpyrrole
CAS No.:129045-09-6
Molecular Formula:C₂₉H₃₆N₂O₄
Molecular Weight:476.616
Hs Code.:

Synonyms:3-<2'-(benzyloxycarbonylamino)phenyl>-5-butyl-2-<2-(1,3-dioxolan-2-yl)ethyl>-1,4-dimethylpyrrole

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Chemical Property of 3-<2'-(benzyloxycarbonylamino)phenyl>-5-butyl-2-<2-(1,3-dioxolan-2-yl)ethyl>-1,4-dimethylpyrrole

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Technology Process of 3-<2'-(benzyloxycarbonylamino)phenyl>-5-butyl-2-<2-(1,3-dioxolan-2-yl)ethyl>-1,4-dimethylpyrrole

There total 8 articles about 3-<2'-(benzyloxycarbonylamino)phenyl>-5-butyl-2-<2-(1,3-dioxolan-2-yl)ethyl>-1,4-dimethylpyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 129045-08-5
3-(2'-aminophenyl)-5-butyl-2-<2-(1,3-dioxolan-2-yl)ethyl>-1,4-dimethylpyrrole

: 129045-09-6
3-<2'-(benzyloxycarbonylamino)phenyl>-5-butyl-2-<2-(1,3-dioxolan-2-yl)ethyl>-1,4-dimethylpyrrole

Guidance literature:: With pyridine; In 1,2-dimethoxyethane; for 1h; Ambient temperature;

Reference yield:

: 129045-01-8
1,4-dimethyl-3-(2'-nitrophenyl)pyrrole-2-carbaldehyde

: 129045-09-6
3-<2'-(benzyloxycarbonylamino)phenyl>-5-butyl-2-<2-(1,3-dioxolan-2-yl)ethyl>-1,4-dimethylpyrrole

Guidance literature:: Multi-step reaction with 8 steps

1: 97 percent / NaH / 1,2-dimethoxy-ethane / 6 h / Ambient temperature

2: 64 percent / 36percent HCl / tetrahydrofuran / 7 h / 0 °C

3: 85 percent / 3 eq DIBAL-H / CH₂Cl₂ / 2 h / -70 °C

4: 67 percent / MnO₂ / CCl₄ / 1.5 h / Ambient temperature

5: 75 percent / pyridinium tosylate / benzene / Heating

6: 93 percent / hydrazine hydrate / aq. Raney Nickel R 50percent / ethanol / 1.5 h / 60 °C

7: 83 percent / H₂ / Pd/C 10percent / ethanol / 12 h / 760 Torr

8: 67 percent / pyridine / 1,2-dimethoxy-ethane / 1 h / Ambient temperature

With pyridine; hydrogenchloride; manganese(IV) oxide; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; hydrazine hydrate; palladium on activated charcoal; Raney Nickel R; In tetrahydrofuran; tetrachloromethane; 1,2-dimethoxyethane; ethanol; dichloromethane; benzene;

Reference yield:

: 156454-57-8
5-(but-1-enyl)-1,4-dimethyl-3-(2'-nitrophenyl)-2-(2-formylvinyl)pyrrole

: 129045-09-6
3-<2'-(benzyloxycarbonylamino)phenyl>-5-butyl-2-<2-(1,3-dioxolan-2-yl)ethyl>-1,4-dimethylpyrrole

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / pyridinium tosylate / benzene / Heating

2: 93 percent / hydrazine hydrate / aq. Raney Nickel R 50percent / ethanol / 1.5 h / 60 °C

3: 83 percent / H₂ / Pd/C 10percent / ethanol / 12 h / 760 Torr

4: 67 percent / pyridine / 1,2-dimethoxy-ethane / 1 h / Ambient temperature

With pyridine; hydrogen; pyridinium p-toluenesulfonate; hydrazine hydrate; palladium on activated charcoal; Raney Nickel R; In 1,2-dimethoxyethane; ethanol; benzene;