2-fluoro-4-((6-p-tolyl-5-((2-(trimethylsilyl)ethoxy)methoxy)pyrimidin-4-yl)((2-(trimethylsilyl)ethoxy)methyl)amino)benzonitrile

Base Information

Chemical Name:2-fluoro-4-((6-p-tolyl-5-((2-(trimethylsilyl)ethoxy)methoxy)pyrimidin-4-yl)((2-(trimethylsilyl)ethoxy)methyl)amino)benzonitrile
CAS No.:1264926-90-0
Molecular Formula:C₃₀H₄₁FN₄O₃Si₂
Molecular Weight:580.85
Hs Code.:

Synonyms:2-fluoro-4-((6-p-tolyl-5-((2-(trimethylsilyl)ethoxy)methoxy)pyrimidin-4-yl)((2-(trimethylsilyl)ethoxy)methyl)amino)benzonitrile

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Chemical Property of 2-fluoro-4-((6-p-tolyl-5-((2-(trimethylsilyl)ethoxy)methoxy)pyrimidin-4-yl)((2-(trimethylsilyl)ethoxy)methyl)amino)benzonitrile

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Technology Process of 2-fluoro-4-((6-p-tolyl-5-((2-(trimethylsilyl)ethoxy)methoxy)pyrimidin-4-yl)((2-(trimethylsilyl)ethoxy)methyl)amino)benzonitrile

There total 3 articles about 2-fluoro-4-((6-p-tolyl-5-((2-(trimethylsilyl)ethoxy)methoxy)pyrimidin-4-yl)((2-(trimethylsilyl)ethoxy)methyl)amino)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1264925-01-0
2-fluoro-4-(5-hydroxy-6-p-tolylpyrimidin-4-ylamino)benzonitrile

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1264926-90-0
2-fluoro-4-((6-p-tolyl-5-((2-(trimethylsilyl)ethoxy)methoxy)pyrimidin-4-yl)((2-(trimethylsilyl)ethoxy)methyl)amino)benzonitrile

Guidance literature:: 2-fluoro-4-(5-hydroxy-6-p-tolylpyrimidin-4-ylamino)benzonitrile; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.166667h;

(2-trimethylethylsilylethoxy)methyl chloride; In N,N-dimethyl-formamide; mineral oil;

With ammonium chloride; In water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1264926-86-4
5-(benzyloxy)-4-chloro-6-p-tolylpyrimidine

: 1264926-90-0
2-fluoro-4-((6-p-tolyl-5-((2-(trimethylsilyl)ethoxy)methoxy)pyrimidin-4-yl)((2-(trimethylsilyl)ethoxy)methyl)amino)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1 h / 760.05 Torr

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h

With hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1264926-88-6
4-(5-(benzyloxy)-6-p-tolylpyrimidin-4-ylamino)-2-fluorobenzonitrile

: 1264926-90-0
2-fluoro-4-((6-p-tolyl-5-((2-(trimethylsilyl)ethoxy)methoxy)pyrimidin-4-yl)((2-(trimethylsilyl)ethoxy)methyl)amino)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1 h / 760.05 Torr

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h

With hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;