Technology Process of N-benzyloxy-2-(3-hydroxymethyl-1-adamantyl)acetamide
There total 3 articles about N-benzyloxy-2-(3-hydroxymethyl-1-adamantyl)acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dimethylsulfide borane complex;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 12h;
Inert atmosphere;
DOI:10.1016/j.bmc.2012.12.001
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 20 °C
1.2: 8 h / 20 °C
2.1: dimethylsulfide borane complex / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere
With
dimethylsulfide borane complex; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2012.12.001
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfuric acid / tetrachloromethane / 10 - 20 °C
2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 20 °C
2.2: 8 h / 20 °C
3.1: dimethylsulfide borane complex / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere
With
dimethylsulfide borane complex; sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; tetrachloromethane; dichloromethane;
1.1: |Koch-Haaf Carboxylation;
DOI:10.1016/j.bmc.2012.12.001
