1-[6-(4-chloro-4'-{4-[(2,2-difluorocyclopropyl)methyl]piperazin-1-yl}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

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Chemical Name:1-[6-(4-chloro-4'-{4-[(2,2-difluorocyclopropyl)methyl]piperazin-1-yl}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
CAS No.:1374342-33-2
Molecular Formula:C₃₀H₂₅ClF₅N₅O₂
Molecular Weight:618.006
Hs Code.:

Synonyms:1-[6-(4-chloro-4'-{4-[(2,2-difluorocyclopropyl)methyl]piperazin-1-yl}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

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Chemical Property of 1-[6-(4-chloro-4'-{4-[(2,2-difluorocyclopropyl)methyl]piperazin-1-yl}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

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Technology Process of 1-[6-(4-chloro-4'-{4-[(2,2-difluorocyclopropyl)methyl]piperazin-1-yl}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

There total 8 articles about 1-[6-(4-chloro-4'-{4-[(2,2-difluorocyclopropyl)methyl]piperazin-1-yl}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374342-05-8
ethyl 1-{6-[5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1374342-37-6
C₁₄H₁₇BrF₂N₂

: 1374342-33-2
1-[6-(4-chloro-4'-{4-[(2,2-difluorocyclopropyl)methyl]piperazin-1-yl}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: ethyl 1-{6-[5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate; C₁₄H₁₇BrF₂N₂; With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; acetonitrile; at 85 ℃; for 2h; Inert atmosphere;

With water; sodium hydroxide; In 1,4-dioxane; at 60 ℃; for 0.25h;

Reference yield:

: 66698-28-0
1-(4-bromophenyl)piperazine

: 1374342-33-2
1-[6-(4-chloro-4'-{4-[(2,2-difluorocyclopropyl)methyl]piperazin-1-yl}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 50 °C

2.1: borane-THF / tetrahydrofuran / 1 h / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / acetonitrile; water / 2 h / 85 °C / Inert atmosphere

3.2: 0.25 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; borane-THF; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1374342-35-4
[4-(4-bromophenyl)piperazin-1-yl](2,2-difluorocyclopropyl)methanone

: 1374342-33-2
1-[6-(4-chloro-4'-{4-[(2,2-difluorocyclopropyl)methyl]piperazin-1-yl}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: borane-THF / tetrahydrofuran / 1 h / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / acetonitrile; water / 2 h / 85 °C / Inert atmosphere

2.2: 0.25 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; borane-THF; sodium carbonate; In tetrahydrofuran; water; acetonitrile;