2',3'-didehydro-2',3'-dideoxy-5'-(O-tert-butyldiphenylsilyl)-2'-(2-(trimethylsilyl)ethyl)thiocytidine

Base Information

Chemical Name:2',3'-didehydro-2',3'-dideoxy-5'-(O-tert-butyldiphenylsilyl)-2'-(2-(trimethylsilyl)ethyl)thiocytidine
CAS No.:953792-20-6
Molecular Formula:C₃₀H₄₁N₃O₃SSi₂
Molecular Weight:579.911
Hs Code.:

Synonyms:2',3'-didehydro-2',3'-dideoxy-5'-(O-tert-butyldiphenylsilyl)-2'-(2-(trimethylsilyl)ethyl)thiocytidine

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Chemical Property of 2',3'-didehydro-2',3'-dideoxy-5'-(O-tert-butyldiphenylsilyl)-2'-(2-(trimethylsilyl)ethyl)thiocytidine

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Technology Process of 2',3'-didehydro-2',3'-dideoxy-5'-(O-tert-butyldiphenylsilyl)-2'-(2-(trimethylsilyl)ethyl)thiocytidine

There total 6 articles about 2',3'-didehydro-2',3'-dideoxy-5'-(O-tert-butyldiphenylsilyl)-2'-(2-(trimethylsilyl)ethyl)thiocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 953792-26-2
C₃₁H₄₅N₃O₆Si₂S₂

: 953792-20-6
2',3'-didehydro-2',3'-dideoxy-5'-(O-tert-butyldiphenylsilyl)-2'-(2-(trimethylsilyl)ethyl)thiocytidine

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 48h;
DOI:10.1021/ol071088p

Reference yield:

: 947322-34-1
N-4-benzoyl-3'-(O-mesyl)-5'-(O-tert-butyldiphenylsilyl)-2'-(2-(trimethylsilyl)ethyl)thiocytidine

: 953792-20-6
2',3'-didehydro-2',3'-dideoxy-5'-(O-tert-butyldiphenylsilyl)-2'-(2-(trimethylsilyl)ethyl)thiocytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / aq. ammonia / ethanol / 24 h / 20 °C

2: 72 percent / potassium carbonate / acetonitrile / 48 h / 20 °C

With ammonium hydroxide; potassium carbonate; In ethanol; acetonitrile;
DOI:10.1021/ol071088p

Reference yield:

: 947322-46-5
5'-O-(tert-butyldiphenylsilyl)-2'-(2-(trimethylsilyl)ethyl)thiocytidine

: 953792-20-6
2',3'-didehydro-2',3'-dideoxy-5'-(O-tert-butyldiphenylsilyl)-2'-(2-(trimethylsilyl)ethyl)thiocytidine

Guidance literature:: Multi-step reaction with 4 steps

1: dimethylformamide / 24 h / Heating

2: 1.57 g / pyridine / 15 h / 20 °C

3: 95 percent / aq. ammonia / ethanol / 24 h / 20 °C

4: 72 percent / potassium carbonate / acetonitrile / 48 h / 20 °C

With pyridine; ammonium hydroxide; potassium carbonate; In ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol071088p