8(R)-(tert-butoxycarbonylamino)-6-<1(R)-phenylethyl>-6-azaspiro<3.4>octane

Base Information

• Chemical Name: 8(R)-(tert-butoxycarbonylamino)-6-<1(R)-phenylethyl>-6-azaspiro<3.4>octane
• CAS No.: 219323-03-2
• Molecular Formula: C₂₀H₃₀N₂O₂
• Molecular Weight: 330.47
• Mol file: 219323-03-2.mol

Synonyms:8(R)-(tert-butoxycarbonylamino)-6-<1(R)-phenylethyl>-6-azaspiro<3.4>octane

Chemical Property of 8(R)-(tert-butoxycarbonylamino)-6-<1(R)-phenylethyl>-6-azaspiro<3.4>octane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8(R)-(tert-butoxycarbonylamino)-6-<1(R)-phenylethyl>-6-azaspiro<3.4>octane

There total 4 articles about 8(R)-(tert-butoxycarbonylamino)-6-<1(R)-phenylethyl>-6-azaspiro<3.4>octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + 8(R)-amino-6-<1(R)-phenylethyl>-6-azaspiro<3.4>octane (219323-01-0) → 8(R)-(tert-butoxycarbonylamino)-6-<1(R)-phenylethyl>-6-azaspiro<3.4>octane (219323-03-2)

Guidance literature:

8(R)-amino-6-<1(R)-phenylethyl>-6-azaspiro<3.4>octane; With sodium hydrogencarbonate; In water; acetonitrile; at 20 ℃;

di-tert-butyl dicarbonate; In water; acetonitrile; at 20 ℃;

DOI:10.1016/j.bmc.2018.01.021

Reference yield:

8-hydroxyimino-6-<1(R)-phenylethyl>-5-oxo-6-azaspiro<3.4>octane (219322-98-2) → 8(R)-(tert-butoxycarbonylamino)-6-<1(R)-phenylethyl>-6-azaspiro<3.4>octane (219323-03-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 22 percent / H₂ / Raney nickel / methanol / 15 h

2: LiAlH₄ / tetrahydrofuran / 2.5 h / Heating

3: tetrahydrofuran / 0.5 h / Ambient temperature

With lithium aluminium tetrahydride; hydrogen; nickel; In tetrahydrofuran; methanol;

DOI:10.1248/cpb.46.1710

Reference yield:

8(R)-amino-6-<1(R)-phenylethyl>-5-oxo-6-azaspiro<3.4>octane (219322-99-3) → 8(R)-(tert-butoxycarbonylamino)-6-<1(R)-phenylethyl>-6-azaspiro<3.4>octane (219323-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / 2.5 h / Heating

2: tetrahydrofuran / 0.5 h / Ambient temperature

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1248/cpb.46.1710

upstream raw materials:

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

8(R)-amino-6-<1(R)-phenylethyl>-6-azaspiro<3.4>octane

8(R)-amino-6-<1(R)-phenylethyl>-5-oxo-6-azaspiro<3.4>octane

8-hydroxyimino-6-<1(R)-phenylethyl>-5-oxo-6-azaspiro<3.4>octane