N-[((2S,5S)-1-{[3-fiuoro-2-(methyloxy)phenyl]carbonyl}-5-methyl-2-piperidinyl)methyl]-5-(trifluoromethyl)-2-pyridinamine

Base Information

Chemical Name:N-[((2S,5S)-1-{[3-fiuoro-2-(methyloxy)phenyl]carbonyl}-5-methyl-2-piperidinyl)methyl]-5-(trifluoromethyl)-2-pyridinamine
CAS No.:1191044-71-9
Molecular Formula:C₂₁H₂₃F₄N₃O₂
Molecular Weight:425.426
Hs Code.:

Synonyms:N-[((2S,5S)-1-{[3-fiuoro-2-(methyloxy)phenyl]carbonyl}-5-methyl-2-piperidinyl)methyl]-5-(trifluoromethyl)-2-pyridinamine

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Chemical Property of N-[((2S,5S)-1-{[3-fiuoro-2-(methyloxy)phenyl]carbonyl}-5-methyl-2-piperidinyl)methyl]-5-(trifluoromethyl)-2-pyridinamine

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Technology Process of N-[((2S,5S)-1-{[3-fiuoro-2-(methyloxy)phenyl]carbonyl}-5-methyl-2-piperidinyl)methyl]-5-(trifluoromethyl)-2-pyridinamine

There total 8 articles about N-[((2S,5S)-1-{[3-fiuoro-2-(methyloxy)phenyl]carbonyl}-5-methyl-2-piperidinyl)methyl]-5-(trifluoromethyl)-2-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 106428-05-1
3-fluoro-2-methoxybenzoic acid

: 1191044-72-0
N-{[(2S,5S)-5-methyl-2-piperidinyl]methyl}-5-(trifluoromethyl)-2-pyridinamine

: 1191044-71-9
N-[((2S,5S)-1-{[3-fiuoro-2-(methyloxy)phenyl]carbonyl}-5-methyl-2-piperidinyl)methyl]-5-(trifluoromethyl)-2-pyridinamine

Guidance literature:: 3-fluoro-2-methoxybenzoic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

N-{[(2S,5S)-5-methyl-2-piperidinyl]methyl}-5-(trifluoromethyl)-2-pyridinamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 1,1-dimethylethyl (3S)-3-methyl-1-piperidinecarboxylate

: 1191044-71-9
N-[((2S,5S)-1-{[3-fiuoro-2-(methyloxy)phenyl]carbonyl}-5-methyl-2-piperidinyl)methyl]-5-(trifluoromethyl)-2-pyridinamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / diethyl ether; cyclohexane / -78 - -50 °C / Inert atmosphere

1.2: -78 - 0 °C

2.1: dichloromethane / 2 h / 20 °C

2.2: 20 °C

3.1: hydrogen / 20 % Pd(OH)2/C / methanol / 34 h / 760.05 Torr

4.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

6.2: 0 - 20 °C

With N,N,N,N,-tetramethylethylenediamine; hydrogen; sec.-butyllithium; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 20 % Pd(OH)2/C; In methanol; diethyl ether; dichloromethane; cyclohexane; N,N-dimethyl-formamide;

Reference yield:

: 1268817-66-8
1,1-dimethylethyl (2S,5S)-2-formyl-5-methyl-1-piperidinecarboxylate

: 1191044-71-9
N-[((2S,5S)-1-{[3-fiuoro-2-(methyloxy)phenyl]carbonyl}-5-methyl-2-piperidinyl)methyl]-5-(trifluoromethyl)-2-pyridinamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 2 h / 20 °C

1.2: 20 °C

2.1: hydrogen / 20 % Pd(OH)2/C / methanol / 34 h / 760.05 Torr

3.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

5.2: 0 - 20 °C

With hydrogen; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 20 % Pd(OH)2/C; In methanol; dichloromethane; N,N-dimethyl-formamide;