2-<3-<4-chloro-2-(2-fluorobenzoyl)phenyl>-3-oxopropyl>-1H-isoindole-1,3(2H)-dione

Base Information

• Chemical Name: 2-<3-<4-chloro-2-(2-fluorobenzoyl)phenyl>-3-oxopropyl>-1H-isoindole-1,3(2H)-dione
• CAS No.: 78367-94-9
• Molecular Formula: C₂₄H₁₅ClFNO₄
• Molecular Weight: 435.839

Synonyms:2-<3-<4-chloro-2-(2-fluorobenzoyl)phenyl>-3-oxopropyl>-1H-isoindole-1,3(2H)-dione

Chemical Property of 2-<3-<4-chloro-2-(2-fluorobenzoyl)phenyl>-3-oxopropyl>-1H-isoindole-1,3(2H)-dione

Chemical Property:

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Technology Process of 2-<3-<4-chloro-2-(2-fluorobenzoyl)phenyl>-3-oxopropyl>-1H-isoindole-1,3(2H)-dione

There total 1 articles about 2-<3-<4-chloro-2-(2-fluorobenzoyl)phenyl>-3-oxopropyl>-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-[4-chloro-2-(2-fluorobenzoyl)phenyl]-3-phthalimidopropyne (76049-53-1) → 2-<3-<4-chloro-2-(2-fluorobenzoyl)phenyl>-3-oxopropyl>-1H-isoindole-1,3(2H)-dione (78367-94-9)

Guidance literature:

With formic acid; water; mercury(II) sulfate; In dichloromethane; for 0.666667h; Ambient temperature;

DOI:10.1021/jm00355a020

Reference yield: 58.0%

2-<3-<4-chloro-2-(2-fluorobenzoyl)phenyl>-3-oxopropyl>-1H-isoindole-1,3(2H)-dione (78367-94-9) → 2-[2-Bromo-3-[4-chloro-2-(2-fluorobenzoyl)phenyl]-3-oxopropyl]-1H-isoindole-1,3(2H)-dione (78367-93-8)

Guidance literature:

With copper(ll) bromide; In tetrahydrofuran; chloroform; ethyl acetate; for 0.5h; Heating;

DOI:10.1021/jm00355a020

Reference yield:

2-<3-<4-chloro-2-(2-fluorobenzoyl)phenyl>-3-oxopropyl>-1H-isoindole-1,3(2H)-dione (78367-94-9) → 2-{4-[4-Chloro-2-(2-fluoro-benzoyl)-phenyl]-2-methyl-thiazol-5-ylmethyl}-isoindole-1,3-dione (78367-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / CuBr₂ / tetrahydrofuran; ethyl acetate; CHCl₃ / 0.5 h / Heating

2: 99 percent / SO₂ / dimethylformamide / 1 h / Heating

With sulfur dioxide; copper(ll) bromide; In tetrahydrofuran; chloroform; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm00355a020

upstream raw materials:

1-[4-chloro-2-(2-fluorobenzoyl)phenyl]-3-phthalimidopropyne

Downstream raw materials:

2-[2-Bromo-3-[4-chloro-2-(2-fluorobenzoyl)phenyl]-3-oxopropyl]-1H-isoindole-1,3(2H)-dione

8-Chloro-6-(2-fluorophenyl)-2-methyl-4H-thiazolo[5,4-d][2]benzazepine

8-chloro-6-(2-fluorophenyl)-4H-thiazolo[5,4-d][2]benzazepin-2-amine

2-{4-[4-Chloro-2-(2-fluoro-benzoyl)-phenyl]-2-methyl-thiazol-5-ylmethyl}-isoindole-1,3-dione

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