4E-(2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-phenyl-3-(N-diphenylphosphinoylamine)-4-penten-1-one

Base Information

Chemical Name:4E-(2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-phenyl-3-(N-diphenylphosphinoylamine)-4-penten-1-one
CAS No.:528838-78-0
Molecular Formula:C₃₀H₂₈NO₄P
Molecular Weight:497.53
Hs Code.:

Synonyms:4E-(2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-phenyl-3-(N-diphenylphosphinoylamine)-4-penten-1-one

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Chemical Property of 4E-(2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-phenyl-3-(N-diphenylphosphinoylamine)-4-penten-1-one

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Technology Process of 4E-(2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-phenyl-3-(N-diphenylphosphinoylamine)-4-penten-1-one

There total 1 articles about 4E-(2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-phenyl-3-(N-diphenylphosphinoylamine)-4-penten-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 224321-19-1
2-hydroxy-1-(2-methoxyphenyl)ethanone

: 743430-40-2
P,P-diphenyl-N-((1E,2E)-3-phenylallylidene)phosphinic amide

: (2S,3R)-4E-2-hydroxy-1-(2-methoxyphenyl)-3-phenyl-3-(N-diphenylphosphinoylamine)-4-penten-1-one

: 528838-78-0
4E-(2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-phenyl-3-(N-diphenylphosphinoylamine)-4-penten-1-one

: (2R,3S)-4E-2-hydroxy-1-(2-methoxyphenyl)-3-phenyl-3-(N-diphenylphosphinoylamine)-4-penten-1-one

Guidance literature:: With (S,S)bis(2,2'-dihydroxy[1,1']binaphthalenyl-3-ylmethyl)ether; 3 A molecular sieve; diethylzinc; In tetrahydrofuran; hexane; at -30 ℃; for 7h; Title compound not separated from byproducts;
DOI:10.1021/ja034787f

Reference yield:

: 528838-78-0
4E-(2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-phenyl-3-(N-diphenylphosphinoylamine)-4-penten-1-one

: (E)-(2R,3R)-3-Amino-2-hydroxy-1-(2-methoxy-phenyl)-5-phenyl-pent-4-en-1-one

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/ja034787f

Reference yield:

: 528838-78-0
4E-(2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-phenyl-3-(N-diphenylphosphinoylamine)-4-penten-1-one

: (4R,5R)-5-(2-Methoxy-benzoyl)-4-((E)-styryl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / tetrahydrofuran / 1 h / 20 °C

2: pyridine / CH₂Cl₂ / 0.5 h / -78 °C

With pyridine; hydrogenchloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja034787f