[4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL]THIOPHEN-2-YLMETHYLENE amine

Base Information

Chemical Name:[4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL]THIOPHEN-2-YLMETHYLENE amine
CAS No.:639784-75-1
Molecular Formula:C₁₆H₁₁F₃N₂S₂
Molecular Weight:352.404
Hs Code.:

Synonyms:[4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL]THIOPHEN-2-YLMETHYLENE amine

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Chemical Property of [4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL]THIOPHEN-2-YLMETHYLENE amine

Chemical Property:

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Technology Process of [4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL]THIOPHEN-2-YLMETHYLENE amine

There total 5 articles about [4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL]THIOPHEN-2-YLMETHYLENE amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.5%

: 639784-21-7
4-METHYL-2-(4-TRIFLUOROMETHYL-PHENYL)-THIAZOL-5-YLAMINE

: 639784-75-1
[4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL]THIOPHEN-2-YLMETHYLENE amine

Guidance literature:: With thiophene-2-carbaldehyde; In ethanol; for 12h;

Reference yield:

: 455-18-5
4-CF₃C₆H₄CN

: 639784-75-1
[4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL]THIOPHEN-2-YLMETHYLENE amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: thioacetamide / DMF (N,N-dimethyl-formamide) / 30.15 h / 70 - 95 °C

2.1: ethyl 2-chloro-3-oxo-butyrate / ethanol / 12 h

2.2: 3 h

3.1: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 2 h

4.1: trifluoroacetic acid / 1 h

5.1: thiophene-2-carbaldehyde / ethanol / 12 h

With thiophene-2-carbaldehyde; diphenyl phosphoryl azide; thioacetamide; triethylamine; trifluoroacetic acid; ethyl 2-chloro-3-oxo-butyrate; In DMF (N,N-dimethyl-formamide); ethanol; tert-butyl alcohol;

Reference yield:

: 639784-20-6
[4-METHYL-2-(4-TRIFLUOROMETHYL-PHENYL)-THIAZOL-5-YI]-CARBAMIC acid TERT-BUTYL ester

: 639784-75-1
[4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL]THIOPHEN-2-YLMETHYLENE amine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 1 h

2: thiophene-2-carbaldehyde / ethanol / 12 h

With thiophene-2-carbaldehyde; trifluoroacetic acid; In ethanol;