4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

Base Information

• Chemical Name: 4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one
• CAS No.: 1441754-44-4
• Molecular Formula: C₂₂H₂₂ClN₃O₂
• Molecular Weight: 395.889

Synonyms:4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

Chemical Property of 4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

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Technology Process of 4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

There total 1 articles about 4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-chloro-2-methyl-phenyl)-3-isopropyl-5-(4-methoxy-benzyl)-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one (1441754-52-4) → 4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one (1441754-44-4)

Guidance literature:

With ammonium cerium (IV) nitrate; In water; acetonitrile; at 20 ℃; for 48h;

Reference yield:

4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one (1441754-44-4) + 2-chloropyridine-4-boronic acid (458532-96-2) → 4-(4-chloro-2-methyl-phenyl)-5-(2-chloro-pyridin-4-yl)-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one (1441754-36-4)

Guidance literature:

With copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

2-chloro-4-iodo-5-methoxy-pyridine (1211516-07-2) + 4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one (1441754-44-4) → 5-(2-chloro-5-methoxy-pyridin-4-yl)-4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one (1441754-60-4)

Guidance literature:

With potassium phosphate; copper(l) iodide; rac-diaminocyclohexane; In 1,4-dioxane; for 48h; Reflux;

upstream raw materials:

4-(4-chloro-2-methyl-phenyl)-3-isopropyl-5-(4-methoxy-benzyl)-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

Downstream raw materials:

4-(4-chloro-2-methyl-phenyl)-5-(2-chloro-pyridin-4-yl)-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

5-(2-chloro-5-methoxy-pyridin-4-yl)-4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

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