4,4,4,4',4',4'-Hexafluorovaline,ethylester

Base Information

• Chemical Name: 4,4,4,4',4',4'-Hexafluorovaline,ethylester
• CAS No.: 78185-92-9
• Molecular Formula: C₇H₉F₆NO₂
• Molecular Weight: 253.144
• Hs Code.: 2922498590
• Mol file: 78185-92-9.mol

Synonyms:DL-Hfv-OEt

Chemical Property of 4,4,4,4',4',4'-Hexafluorovaline,ethylester

Chemical Property:

• Refractive Index: 1.3600
• Boiling Point: 70-72℃/10mm
• PKA: 3.12±0.37(Predicted)
• Density: 1.410 g/cm3

Purity/Quality:

98%min ^*data from raw suppliers

4,4,4,4',4',4'-Hexafluorovaline, ethyl ester 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4,4,4',4',4'-Hexafluorovaline,ethylester

There total 2 articles about 4,4,4,4',4',4'-Hexafluorovaline,ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethyl 4,4,4-trifluoro-3-(trifluoromethyl)crotonate (1513-60-6) → DL-Hfv-OEt (78185-92-9)

Guidance literature:

With ammonia; In diethyl ether; at 195 - 293 ℃;

DOI:10.1246/bcsj.69.1383

Reference yield:

(4,4,4)-trifluoro-3-(trifluoromethyl)but-2-enoic acid (1763-28-6) → DL-Hfv-OEt (78185-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄

2: NH₃

With sulfuric acid; ammonia;

DOI:10.1007/BF00912052

Reference yield: 91.0%

DL-Hfv-OEt (78185-92-9) → (RS)-hexafluorovaline (16063-80-2)

Guidance literature:

With hydrogenchloride; for 7h; Heating;

DOI:10.1246/bcsj.69.1383

upstream raw materials:

ethyl 4,4,4-trifluoro-3-(trifluoromethyl)crotonate

(4,4,4)-trifluoro-3-(trifluoromethyl)but-2-enoic acid

Downstream raw materials:

(RS)-hexafluorovaline

4,4,4-trifluoro-2-(3,4,5-trifluoro-benzenesulfonylamino)-3-trifluoromethyl-butyric acid ethyl ester

N^α-(tert-butyloxycarbonyl)-DL-hexafluorovaline