Gadodiamide hydrate

Base Information

• Chemical Name: Gadodiamide hydrate
• CAS No.: 131410-48-5
• Molecular Formula: C16H26GdN5O8
• Molecular Weight: 573.661
• Hs Code.: 2846909000
• UNII: 84F6U3J2R6
• DSSTox Substance ID: DTXSID201019701
• Wikipedia: Gadodiamide
• NCI Thesaurus Code: C65795
• RXCUI: 41144
• Mol file: 131410-48-5.mol

Synonyms:gadodiamide;Gd-DTPA bis-(methylamide);Gd-DTPA-BMA;Omniscan;Omniscan Unique Softpack

Chemical Property of Gadodiamide hydrate

Chemical Property:

• Vapor Pressure: 6.54E-26mmHg at 25°C
• Boiling Point: 769.1 °C at 760 mmHg
• Flash Point: 419 °C
• PSA: 146.82000
• LogP: -2.99760
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Methanol (Slightly, Heated), Water (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 13
• Exact Mass: 574.10225
• Heavy Atom Count: 30
• Complexity: 527

Purity/Quality:

99%, ^*data from raw suppliers

Gadodiamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC(=O)CN(CCN(CCN(CC(=O)NC)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].[Gd+3]
• Recent ClinicalTrials: Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years
• Recent EU Clinical Trials: Exploratory evaluation of the potential for long-term retention of Gadolinium in the bones of patients who have received Gadolinium based Contrast Agents according to their medical history.
• Recent NIPH Clinical Trials: Visualization of endolymphatic hydrops in Meniere's disease by MRI
• Uses: Gadodiamide is an apoptosis inducing agent used in chondrocytes. It is primarily used in muscoskeletal diagnosis as a contrast agent.

Technology Process of Gadodiamide hydrate

There total 1 articles about Gadodiamide hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

gadolinium(III) chloride (10138-52-0) + H3DTPA-BMA (119895-95-3) → gadodiamide (131410-48-5)

Guidance literature:

With NaOH; In hydrogenchloride; water; soln. of GdCl3 in aq. HCl mixed with aq. soln. of ligand, pH adjusted to6 by NaOH;

DOI:10.1021/ic102390p

upstream raw materials:

gadolinium(III) chloride

H₃DTPA-BMA

Refernces