(2S,6S)-2,6-diphenyltetrahydro-2H-thiopyran

Base Information

• Chemical Name: (2S,6S)-2,6-diphenyltetrahydro-2H-thiopyran
• CAS No.: 1438891-78-1
• Molecular Formula: C₁₇H₁₈S
• Molecular Weight: 254.396
• Mol file: 1438891-78-1.mol

Synonyms:(2S,6S)-2,6-diphenyltetrahydro-2H-thiopyran

Chemical Property of (2S,6S)-2,6-diphenyltetrahydro-2H-thiopyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,6S)-2,6-diphenyltetrahydro-2H-thiopyran

There total 5 articles about (2S,6S)-2,6-diphenyltetrahydro-2H-thiopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(R,R)-1,5-bis(methanesulfonyloxy)-1,5-diphenylpentane (295328-89-1) → (2S,6S)-2,6-diphenyltetrahydro-2H-thiopyran (1438891-78-1)

Guidance literature:

With sodiumsulfide nonahydrate; In dimethyl sulfoxide; at 25 ℃; for 36h;

DOI:10.1016/j.tetasy.2013.03.021

Reference yield:

glutaric anhydride, (108-55-4) → (2S,6S)-2,6-diphenyltetrahydro-2H-thiopyran (1438891-78-1)

Guidance literature:

Multi-step reaction with 5 steps

1: phosphorus pentachloride / 24 h / Reflux

2: aluminum (III) chloride

3: borane-THF; (S)-diphenylprolinol; Trimethyl borate

4: triethylamine / dichloromethane

5: sodiumsulfide nonahydrate / dimethyl sulfoxide / 36 h / 25 °C

With aluminum (III) chloride; borane-THF; sodiumsulfide nonahydrate; Trimethyl borate; (S)-diphenylprolinol; phosphorus pentachloride; triethylamine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.tetasy.2013.03.021

Reference yield:

(-)-(S,S)-1,5-diphenylpentane-1,5-diol (195443-92-6) → (2S,6S)-2,6-diphenyltetrahydro-2H-thiopyran (1438891-78-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane

2: sodiumsulfide nonahydrate / dimethyl sulfoxide / 36 h / 25 °C

With sodiumsulfide nonahydrate; triethylamine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.tetasy.2013.03.021

upstream raw materials:

glutaric anhydride,

gloutaric dichloride

1,5-diphenyl-1,5-pentanedione

(-)-(S,S)-1,5-diphenylpentane-1,5-diol

Downstream raw materials:

(2S,6S)-2,6-diphenyltetrahydro-2H-thiopyran-1,1-dioxide