N-allyl-N-{4-methyl-1-[1-(4-nitro-phenyl)-ethyl]-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-malonamic acid methyl ester

Base Information

• Chemical Name: N-allyl-N-{4-methyl-1-[1-(4-nitro-phenyl)-ethyl]-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-malonamic acid methyl ester
• CAS No.: 882035-32-7
• Molecular Formula: C₂₇H₂₉N₃O₆
• Molecular Weight: 491.544
• Mol file: 882035-32-7.mol

Synonyms:N-allyl-N-{4-methyl-1-[1-(4-nitro-phenyl)-ethyl]-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-malonamic acid methyl ester

Chemical Property of N-allyl-N-{4-methyl-1-[1-(4-nitro-phenyl)-ethyl]-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-malonamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-allyl-N-{4-methyl-1-[1-(4-nitro-phenyl)-ethyl]-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-malonamic acid methyl ester

There total 4 articles about N-allyl-N-{4-methyl-1-[1-(4-nitro-phenyl)-ethyl]-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-malonamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-Allylamino-4-methyl-1-[(S)-1-(4-nitro-phenyl)-ethyl]-6-phenyl-5,6-dihydro-1H-pyridin-2-one (882035-27-0) + 3-chloro-3-oxopropanoic acid methyl ester (37517-81-0) → N-allyl-N-{4-methyl-1-[1-(4-nitro-phenyl)-ethyl]-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-malonamic acid methyl ester (882035-32-7)

Guidance literature:

With TEA; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tetasy.2005.12.006

Reference yield:

[(S)-1-(4-Nitro-phenyl)-ethyl]-[1-phenyl-meth-(E)-ylidene]-amine → N-allyl-N-{4-methyl-1-[1-(4-nitro-phenyl)-ethyl]-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-malonamic acid methyl ester (882035-32-7)

Guidance literature:

Multi-step reaction with 3 steps

1: TEA / CH₂Cl₂ / Heating

2: 48 h / Heating

3: TEA / CH₂Cl₂ / 0 - 20 °C

With TEA; In dichloromethane;

DOI:10.1016/j.tetasy.2005.12.006

Reference yield:

(R)-3-Bromo-4-methyl-1-[(S)-1-(4-nitro-phenyl)-ethyl]-6-phenyl-5,6-dihydro-1H-pyridin-2-one (882035-23-6) → N-allyl-N-{4-methyl-1-[1-(4-nitro-phenyl)-ethyl]-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-malonamic acid methyl ester (882035-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 h / Heating

2: TEA / CH₂Cl₂ / 0 - 20 °C

With TEA; In dichloromethane;

DOI:10.1016/j.tetasy.2005.12.006

upstream raw materials:

(R)-3-Allylamino-4-methyl-1-[(S)-1-(4-nitro-phenyl)-ethyl]-6-phenyl-5,6-dihydro-1H-pyridin-2-one

3-chloro-3-oxopropanoic acid methyl ester

(R)-3-Bromo-4-methyl-1-[(S)-1-(4-nitro-phenyl)-ethyl]-6-phenyl-5,6-dihydro-1H-pyridin-2-one

2-bromo-3-methyl-but-2-enoyl chloride

Downstream raw materials:

N-{1-[1-(4-amino-phenyl)-ethyl]-4-methyl-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-N-propyl-malonamic acid methyl ester

C₃₈H₅₁N₅O₈