2-[3-[(3-{[(2R)-1-(tert-Butoxycarbonyl)pyrrolidinyl]methoxy}phenethyl)amino]-6-methyl-2-oxo-1(2 H)-pyrazinyl]acetic acid

Base Information

• Chemical Name: 2-[3-[(3-{[(2R)-1-(tert-Butoxycarbonyl)pyrrolidinyl]methoxy}phenethyl)amino]-6-methyl-2-oxo-1(2 H)-pyrazinyl]acetic acid
• CAS No.: 259538-77-7
• Molecular Formula: C₂₅H₃₄N₄O₆
• Molecular Weight: 486.568

Synonyms:2-[3-[(3-{[(2R)-1-(tert-Butoxycarbonyl)pyrrolidinyl]methoxy}phenethyl)amino]-6-methyl-2-oxo-1(2 H)-pyrazinyl]acetic acid

Chemical Property of 2-[3-[(3-{[(2R)-1-(tert-Butoxycarbonyl)pyrrolidinyl]methoxy}phenethyl)amino]-6-methyl-2-oxo-1(2 H)-pyrazinyl]acetic acid

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Technology Process of 2-[3-[(3-{[(2R)-1-(tert-Butoxycarbonyl)pyrrolidinyl]methoxy}phenethyl)amino]-6-methyl-2-oxo-1(2 H)-pyrazinyl]acetic acid

There total 1 articles about 2-[3-[(3-{[(2R)-1-(tert-Butoxycarbonyl)pyrrolidinyl]methoxy}phenethyl)amino]-6-methyl-2-oxo-1(2 H)-pyrazinyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-Butyl (2 R)-2-({3-[2-({4-[2-(benzyloxy)-2-oxoethyl]-6-chloro-5-methyl-3-oxo-3,4-dihydro-2-pyrazinyl}amino)ethyl]phenoxy)methyl)-1-pyrrolidinecarboxylate (259538-76-6) → 2-[3-[(3-{[(2R)-1-(tert-Butoxycarbonyl)pyrrolidinyl]methoxy}phenethyl)amino]-6-methyl-2-oxo-1(2 H)-pyrazinyl]acetic acid (259538-77-7)

Guidance literature:

With sodium hydroxide; ammonium formate; palladium on charcoal; In methanol; water;

Reference yield:

1-(3-methyl-1H-indol-5-yl)methanamine (933735-99-0) + 2-[3-[(3-{[(2R)-1-(tert-Butoxycarbonyl)pyrrolidinyl]methoxy}phenethyl)amino]-6-methyl-2-oxo-1(2 H)-pyrazinyl]acetic acid (259538-77-7) → tert-Butyl (2 R)-2-{[3-(2-{[5-methyl-4-(2-{[(3-methyl-1 H-indol-5-yl)methyl]amino}-2-oxoethyl)-3-oxo-3,4-dihydro-2-pyrazinyl]amino}ethyl)phenoxy]methyl}-1-pyrrolidinecarboxylate (259538-78-8)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; In N,N-dimethyl-formamide;

upstream raw materials:

tert-Butyl (2 R)-2-({3-[2-({4-[2-(benzyloxy)-2-oxoethyl]-6-chloro-5-methyl-3-oxo-3,4-dihydro-2-pyrazinyl}amino)ethyl]phenoxy)methyl)-1-pyrrolidinecarboxylate

Downstream raw materials:

tert-Butyl (2 R)-2-{[3-(2-{[5-methyl-4-(2-{[(3-methyl-1 H-indol-5-yl)methyl]amino}-2-oxoethyl)-3-oxo-3,4-dihydro-2-pyrazinyl]amino}ethyl)phenoxy]methyl}-1-pyrrolidinecarboxylate

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