N-(1-(1-aminoisoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butylbenzenesulfonamide

Base Information

Chemical Name:N-(1-(1-aminoisoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butylbenzenesulfonamide
CAS No.:1452182-83-0
Molecular Formula:C₂₃H₂₅N₅O₂S
Molecular Weight:435.55
Hs Code.:

Synonyms:N-(1-(1-aminoisoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butylbenzenesulfonamide

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Chemical Property of N-(1-(1-aminoisoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butylbenzenesulfonamide

Chemical Property:

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Technology Process of N-(1-(1-aminoisoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butylbenzenesulfonamide

There total 7 articles about N-(1-(1-aminoisoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1452184-04-1
C₂₇H₃₃N₅O₂S

: 1452182-83-0
N-(1-(1-aminoisoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butylbenzenesulfonamide

Guidance literature:: With trifluoroacetic acid; at 80 ℃; for 1.5h;

Reference yield:

: 1452184-00-7
1-(isoquinolin-5-yl)-3-methyl-1H-pyrazol-5-amine

: 1452182-83-0
N-(1-(1-aminoisoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: dmap / dichloromethane / 15 h / 20 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 20 °C

3: p-toluenesulfonylanhydride / dichloromethane; toluene / 2 h / 0 - 20 °C

4: pyridine; dmap / 1 h / 85 °C

5: trifluoroacetic acid / 1.5 h / 80 °C

With pyridine; dmap; p-toluenesulfonylanhydride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane; toluene;

Reference yield:

: 1125-60-6
isoquinolin-5-ylamine

: 1452182-83-0
N-(1-(1-aminoisoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / water / 0.5 h / 0 °C

1.2: 1 h / 0 - 20 °C

1.3: 4.5 h / 0 - 20 °C

2.1: ethanol / 2 h / 80 °C

3.1: dmap / dichloromethane / 15 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 20 °C

5.1: p-toluenesulfonylanhydride / dichloromethane; toluene / 2 h / 0 - 20 °C

6.1: pyridine; dmap / 1 h / 85 °C

7.1: trifluoroacetic acid / 1.5 h / 80 °C

With pyridine; hydrogenchloride; dmap; p-toluenesulfonylanhydride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In ethanol; dichloromethane; water; toluene;