tert-butyl (2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
CAS No.:908022-22-0
Molecular Formula:C₂₆H₃₇NO₄Si
Molecular Weight:455.67
Hs Code.:

Synonyms:tert-butyl (2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

There total 2 articles about tert-butyl (2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 908022-22-0
tert-butyl (2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: 1-(tert-butyl) 2-methyl (2S,3S)-3-((tert-butyldiphenylsilyl)oxy)pyrrolidine-1,2-dicarboxylate; With methanol; diazomethyl-trimethyl-silane; In hexane;

tert-butylchlorodiphenylsilane; With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;

With potassium sulfate; lithium borohydride; water; more than 3 stages;

Reference yield:

: 184046-78-4
(2S,3S)-1-tert-butyl-2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate

: 908022-22-0
tert-butyl (2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 12 h / 20 °C

2: lithium borohydride / tetrahydrofuran / 4 h / 0 - 20 °C

With 1H-imidazole; dmap; lithium borohydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/anie.201510418

Reference yield: 76.0%

: 908022-22-0
tert-butyl (2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

: tert-butyl (2S,3S)-3-((tert-butyldiphenylsilyl)oxy)-2-formylpyrrolidine-1-carboxylate

Guidance literature:: With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In dichloromethane; acetonitrile; at 20 ℃; for 4h;
DOI:10.1002/anie.201510418