(R)-t-butyl 4-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-3-(2,4,5-trifluorobenzyl)butanoate

Base Information

Chemical Name:(R)-t-butyl 4-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-3-(2,4,5-trifluorobenzyl)butanoate
CAS No.:1407666-61-8
Molecular Formula:C₂₅H₂₆F₃NO₅
Molecular Weight:477.48
Hs Code.:

Synonyms:(R)-t-butyl 4-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-3-(2,4,5-trifluorobenzyl)butanoate

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Chemical Property of (R)-t-butyl 4-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-3-(2,4,5-trifluorobenzyl)butanoate

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Technology Process of (R)-t-butyl 4-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-3-(2,4,5-trifluorobenzyl)butanoate

There total 4 articles about (R)-t-butyl 4-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-3-(2,4,5-trifluorobenzyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1407666-56-1
(S)-4-benzyl-3-(3-(2,4,5-trifluorophenyl)propanoyl)oxazolidin-2-one

: 1407666-61-8
(R)-t-butyl 4-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-3-(2,4,5-trifluorobenzyl)butanoate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -40 ℃; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 651047-33-5
3-(2,4,5-trifluorophenyl)propanoic acid

: 1407666-61-8
(R)-t-butyl 4-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-3-(2,4,5-trifluorobenzyl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; pivaloyl chloride; lithium chloride / tetrahydrofuran / -20 °C / Inert atmosphere

2: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C / Inert atmosphere

With pivaloyl chloride; triethylamine; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran;

Reference yield:

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 1407666-61-8
(R)-t-butyl 4-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-3-(2,4,5-trifluorobenzyl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; pivaloyl chloride; lithium chloride / tetrahydrofuran / -20 °C / Inert atmosphere

2: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C / Inert atmosphere

With pivaloyl chloride; triethylamine; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran;