(S)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-p-toluenesulfonylpyrrolidine

Base Information

Chemical Name:(S)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-p-toluenesulfonylpyrrolidine
CAS No.:1190695-11-4
Molecular Formula:C₂₁H₂₅NO₄S
Molecular Weight:387.5
Hs Code.:

Synonyms:(S)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-p-toluenesulfonylpyrrolidine

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Chemical Property of (S)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-p-toluenesulfonylpyrrolidine

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Technology Process of (S)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-p-toluenesulfonylpyrrolidine

There total 1 articles about (S)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-p-toluenesulfonylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1190695-10-3
(S)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-hydroxypyrrolidine

: 98-59-9
p-toluenesulfonyl chloride

: 1190695-11-4
(S)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-p-toluenesulfonylpyrrolidine

Guidance literature:: With triethylamine; In dichloromethane; at -10 - 20 ℃;

Reference yield: 69.0%

: 86-29-3
Diphenylacetonitrile

: 1190695-11-4
(S)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-p-toluenesulfonylpyrrolidine

: (3S)-3-(1-carbonitrile-1,1-diphenylmethyl)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidine

Guidance literature:: Diphenylacetonitrile; With sodium hydride; In toluene; for 2h; Reflux;

(S)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-p-toluenesulfonylpyrrolidine; In toluene; for 9h; Reflux;

Reference yield:

: 1190695-11-4
(S)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-p-toluenesulfonylpyrrolidine

: 133099-07-7
(S)-darifenacin hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / toluene / 2 h / Reflux

1.2: 9 h / Reflux

2.1: tetrabutylammomium bromide; potassium hydroxide / iso-butanol / 48 h / Reflux

3.1: hydrogen bromide / water; acetone

With tetrabutylammomium bromide; hydrogen bromide; sodium hydride; potassium hydroxide; In water; acetone; toluene; iso-butanol;