N-(S)-α-phenylethyl-P-t-butylphosphonamidic acid

Base Information

• Chemical Name: N-(S)-α-phenylethyl-P-t-butylphosphonamidic acid
• CAS No.: 103828-95-1
• Molecular Formula: C₁₂H₂₀NO₂P
• Molecular Weight: 241.27
• Mol file: 103828-95-1.mol

Synonyms:N-(S)-α-phenylethyl-P-t-butylphosphonamidic acid

Chemical Property of N-(S)-α-phenylethyl-P-t-butylphosphonamidic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of N-(S)-α-phenylethyl-P-t-butylphosphonamidic acid

There total 1 articles about N-(S)-α-phenylethyl-P-t-butylphosphonamidic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

tert-butyl phosphinyl dichloride (4707-95-3) + (S)-1-phenyl-ethylamine (2627-86-3) → N-(S)-α-phenylethyl-P-t-butylphosphonamidic acid (103828-95-1)

Guidance literature:

In water; Ambient temperature;

Reference yield: 71.0%

N-(S)-α-phenylethyl-P-t-butylphosphonamidic acid (103828-95-1) → N-(S)-α-phenylethyl-P-t-butylphosphonamidic chloride (103828-93-9,103828-94-0)

Guidance literature:

With oxalyl dichloride; In dichloromethane; for 1h; Ambient temperature;

Reference yield:

N-(S)-α-phenylethyl-P-t-butylphosphonamidic acid (103828-95-1) → methyl phosphonamidate

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / oxalyl chloride / CH₂Cl₂ / 1 h / Ambient temperature

2: acetonitrile / 25.8 °C

With oxalyl dichloride; In dichloromethane; acetonitrile;

upstream raw materials:

tert-butyl phosphinyl dichloride

(S)-1-phenyl-ethylamine

Downstream raw materials:

N-(S)-α-phenylethyl-P-t-butylphosphonamidic chloride

N-methyl-N'-(S)-α-phenylethyl-P-t-butylphosphonic diamide

N-isopropyl-N'-(S)-α-phenylethyl-P-t-butylphosphonic diamide