Pharmakon1600-01500380

Base Information

Chemical Name:Pharmakon1600-01500380
CAS No.:2668-66-8
Molecular Formula:C22H32 O3
Molecular Weight:344.494
Hs Code.:
NSC Number:757096
Mol file:2668-66-8.mol

Synonyms:Spectrum_000897;Spectrum2_000141;Spectrum3_000488;Spectrum4_000040;Spectrum5_000946;BSPBio_001955;KBioGR_000479;KBioSS_001377;DivK1c_000349;SPECTRUM1500380;SPBio_000242;SCHEMBL12998543;HMS501B11;KBio1_000349;KBio2_001377;KBio2_003945;KBio2_006513;KBio3_001455;NINDS_000349;HMS1920J21;HMS2091B12;Pharmakon1600-01500380;CCG-38940;NSC757096;NSC-757096;IDI1_000349;NCGC00178898-01;SBI-0051435.P003;AB00052035_02;SR-05000001665;SR-05000001665-1;BRD-A20126139-001-02-6;BRD-A20126139-001-03-4

Suppliers and Price of Pharmakon1600-01500380

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Medrysone
25mg
$ 80.00

Sigma-Aldrich
6α-Methyl-11β-hydroxyprogesterone
250mg
$ 71.70

Crysdot
Medrysone 98+%
100mg
$ 50.00

Cayman Chemical
6α-methyl-11β-Hydroxyprogesterone ≥95%
500mg
$ 85.00

Cayman Chemical
6α-methyl-11β-Hydroxyprogesterone ≥95%
250mg
$ 46.00

Cayman Chemical
6α-methyl-11β-Hydroxyprogesterone ≥95%
100mg
$ 26.00

ApexBio Technology
6α-methyl-11β-Hydroxyprogesterone
250mg
$ 64.00

ApexBio Technology
6α-methyl-11β-Hydroxyprogesterone
500mg
$ 118.00

American Custom Chemicals Corporation
MEDRYSONE 95.00%
100MG
$ 885.31

AK Scientific
Medrysone
100mg
$ 135.00

Total 14 raw suppliers

Chemical Property of Pharmakon1600-01500380

Chemical Property:

Vapor Pressure:9.3E-12mmHg at 25°C
Melting Point:155-158°
Boiling Point:492.3°Cat760mmHg
PKA:14.53±0.70(Predicted)
Flash Point:265.7°C
PSA：54.37000
Density:1.13g/cm³
LogP:3.94030
Storage Temp.:2-8°C
Solubility.:Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly, Sonicated)
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:344.23514488
Heavy Atom Count:25
Complexity:650

Purity/Quality:

97% ^*data from raw suppliers

Medrysone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)CC4)C)O)C)C(=O)C
Isomeric SMILES:C[C@H]1CC2C3CC[C@@H]([C@]3(C[C@@H](C2[C@@]4(C1=CC(=O)CC4)C)O)C)C(=O)C
Description 6α-methyl-11β-hydroxy Progesterone is an anti-inflammatory steroid. It is a hydroxylated progesterone that lacks progestational and androgenic activity. It inhibits phytohemagglutinin-activated T cell proliferation in vitro with an IC50 value of 2.9 μg/ml. 6α-methyl-11β-hydroxy Progesterone also inhibits TNF-α production in LPS-stimulated THP-1 cells (IC50 = 30.54 μg/ml). Topical formulations containing 6α-methyl-11β-hydroxyprogesterone have been used to treat inflammatory ocular diseases.
Uses glucocorticoid Medrysone is a corticosteroid that is seen to increase intraocular pressure.
Therapeutic Function Glucocorticoid

Technology Process of Pharmakon1600-01500380

There total 5 articles about Pharmakon1600-01500380 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108442-90-6
3,3;20,20-bis-ethanediyldioxy-6-methyl-pregn-5-en-11-one

: 2668-66-8
medrysone

Guidance literature:: With tetrahydrofuran; lithium aluminium tetrahydride; diethyl ether; Erwaermen des Reaktionsprodukts mit wss.-methanol.H₂SO₄;

Reference yield:

: 14529-56-7
6β-methyl-11-ketoprogesterone

: 2668-66-8
medrysone

Guidance literature:: Multi-step reaction with 2 steps

1: benzene; toluene-4-sulfonic acid / unter Entfernen des entstehenden Wassers

2: LiAlH₄; THF; diethyl ether / Erwaermen des Reaktionsprodukts mit wss.-methanol.H₂SO₄

With tetrahydrofuran; lithium aluminium tetrahydride; diethyl ether; toluene-4-sulfonic acid; benzene;