methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

Base Information

Chemical Name:methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate
CAS No.:1422387-17-4
Molecular Formula:C₂₇H₃₄N₄O₅
Molecular Weight:494.591
Hs Code.:

Synonyms:methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

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Chemical Property of methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

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Technology Process of methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

There total 18 articles about methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1329171-26-7
methyl N-(3-amino-4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}phenyl)carbamate

: 20626-49-7
(R)-2-methylbut-3-enoic acid

: 1422387-17-4
methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

Guidance literature:: With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at -10 - 20 ℃; Inert atmosphere;

Reference yield:

: 1329167-90-9
tert-butyl N-[(1S)-1-[4-(2-amino-4-nitrophenyl)pyridin-2-yl]but-3-en-1-yl]carbamate

: 1422387-17-4
methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: zinc; ammonium chloride / methanol / 4 h

2: pyridine / dichloromethane / 1.5 h / -78 °C

3: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; pyridine / ethyl acetate / -10 - 20 °C / Inert atmosphere

With pyridine; ammonium chloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; zinc; In methanol; dichloromethane; ethyl acetate;

Reference yield:

: 1329171-25-6
tert-butyl N-[(1S)-1-[4-(2,4-diaminophenyl)pyridin-2-yl]but-3-en-1-yl]carbamate

: 1422387-17-4
methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 1.5 h / -78 °C

2: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; pyridine / ethyl acetate / -10 - 20 °C / Inert atmosphere

With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In dichloromethane; ethyl acetate;